School of Nursing, The University of Texas, Austin, USA.
Biol Res Nurs. 2013 Jan;15(1):78-85. doi: 10.1177/1099800411416225. Epub 2011 Aug 5.
Among Hispanics living in the United States, acculturation is associated with an increased risk for preterm birth. Inflammatory pathways are also associated with preterm birth. As such, the current study sought to investigate the potential relationships among preterm birth, acculturation of Hispanic women, and inflammatory markers.
The authors performed an observational study on pregnant Hispanic women in Texas at 22-24 weeks' gestation (n = 470). The authors obtained demographic data prenatally as well as birth outcome data from the medical chart after delivery. The authors obtained venous blood and used plasma to assay interleukin-1 receptor antagonist (IL-1RA), interleukin-6 (IL-6), and interleukin-10 (IL-10). The authors used logistic regression to understand whether the presence or the absence of IL-10 levels was related to acculturation and the risk of preterm birth.
The authors observed interactions between undetectable IL-10 levels and years in the United States and undetectable IL-10 levels and being born in the United States in models predicting preterm birth. Follow-up probes of these interactions suggested that when IL-10 was undetectable, preterm birth became more likely as time living in the United States increased, χ(2) = 5.15 (1, 416), p = .020, odds ratio (OR) = 3.17, and was more likely in participants born in the United States than in those born elsewhere, χ(2) = 5.35 (1, 462), p = .020, OR = 16.78. The authors observed no interactions among acculturation, preterm birth, and IL-1RA and IL-6 levels.
Acculturated Hispanics who lack the protective effects of IL-10 experience a markedly higher risk of preterm birth than nonacculturated Hispanics.
在美国生活的西班牙裔中，文化适应与早产风险增加有关。炎症途径也与早产有关。因此，本研究旨在探讨早产、西班牙裔妇女的文化适应与炎症标志物之间的潜在关系。
作者对德克萨斯州 22-24 周妊娠的西班牙裔孕妇（n=470）进行了一项观察性研究。作者在产前获得了人口统计学数据，并在分娩后从病历中获得了分娩结果数据。作者采集了静脉血，并用血浆检测白细胞介素-1 受体拮抗剂（IL-1RA）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）。作者使用逻辑回归来理解 IL-10 水平的存在或缺失是否与文化适应和早产风险有关。
作者在预测早产的模型中观察到了未检测到的 IL-10 水平与在美国的居住年限以及未检测到的 IL-10 水平与在美国出生之间的相互作用。对这些相互作用的后续研究表明，当 IL-10 无法检测到时，随着在美国居住时间的增加，早产的可能性增加，χ(2)=5.15（1，416），p=0.020，优势比（OR）=3.17，并且在美国出生的参与者比在其他地方出生的参与者更有可能，χ(2)=5.35（1，462），p=0.020，OR=16.78。作者没有观察到文化适应、早产和 IL-1RA 以及 IL-6 水平之间的相互作用。
缺乏 IL-10 保护作用的文化适应的西班牙裔人比非文化适应的西班牙裔人早产的风险明显更高。
