Schizophrenia Program, Department of Psychiatry, Neuroscience Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Schizophr Res. 2012 Jan;134(1):16-9. doi: 10.1016/j.schres.2011.07.025. Epub 2011 Aug 9.
Previous studies have found increased prolactin concentrations in antipsychotic-naïve patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered.
Blood from newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis (13 women and 20 men) and matched controls (12 women and 21 men) was assayed for prolactin, as well as three other hormones that impact prolactin concentrations: thyrotropin-stimulating hormone (TSH), ghrelin, and cortisol.
Patients had significantly higher prolactin concentrations: female patients had a mean [SD] of 37.1 ng/mL [24.9] vs. 13.5 ng/mL [7.2] for female control subjects (p=.001), while male patients had a mean of 15.3 ng/mL [9.5] vs. 7.6 ng/mL [2.2] for male control subjects (p=.006). Patients and control subjects did not differ on concentrations of TSH, ghrelin, or cortisol. The group differences could not be attributed to differences in age, gender, smoking, body mass index, ethnicity, or the socioeconomic status of the family of origin.
Increased prolactin concentrations in antipsychotic-naïve patients do not appear to be due to important confounding variables, or to the effects of elevated TSH, ghrelin, or cortisol.
先前的研究发现，初诊、未使用抗精神病药物的精神分裂症患者催乳素浓度升高。然而，其他激素的作用，以及性别和吸烟等潜在混杂变量的作用尚未得到考虑。
对新诊断的、未经抗精神病药物治疗的非情感性精神病患者（女性 13 例，男性 20 例）和匹配的对照组（女性 12 例，男性 21 例）的血液进行催乳素以及另外三种影响催乳素浓度的激素（促甲状腺激素刺激激素（TSH）、胃饥饿素和皮质醇）检测。
患者的催乳素浓度显著升高：女性患者的平均（SD）为 37.1ng/mL[24.9]，而女性对照组为 13.5ng/mL[7.2]（p=.001），而男性患者的平均水平为 15.3ng/mL[9.5]，而男性对照组为 7.6ng/mL[2.2]（p=.006）。患者和对照组在 TSH、胃饥饿素或皮质醇浓度上没有差异。组间差异不能归因于年龄、性别、吸烟、体重指数、种族、或原籍家庭的社会经济地位的差异。
初诊、未使用抗精神病药物的患者催乳素浓度升高似乎不是由于重要的混杂变量，也不是由于 TSH、胃饥饿素或皮质醇升高所致。
