Dept of Epidemiology, E3.29, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Eur Respir J. 2012 Feb;39(2):385-91. doi: 10.1183/09031936.00184110. Epub 2011 Aug 18.
Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT)1 activity. We assessed the impact of wine and resveratrol intake, and SIRT1 single-nucleotide polymorphisms (SNPs) on lung function in the general population. Effects of red and white wine and resveratrol intake on forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC were analysed in the population-based Doetinchem cohort (n=3,224). Associations of four tagging SIRT1 SNPs with lung function were analysed in the Doetinchem (n=1,152) and Vlagtwedde-Vlaardingen (n=1,390) cohorts. Resveratrol intake was associated with higher FVC levels, and white wine intake with higher FEV(1) levels and lower risk of airway obstruction. SIRT1 SNPs were not significantly associated with level or course of lung function, either directly or indirectly via wine or resveratrol intake. This study shows a positive association of resveratrol intake with lung function in the general population, confirms the previously reported positive association of white wine intake with higher levels of FEV(1), and additionally shows an association with a higher FEV(1)/FVC ratio. These effects probably do not run via SNPs in SIRT1.
饮酒与一般人群的肺功能改善有关，但这种效果的来源尚不清楚。白藜芦醇是葡萄酒中的一种多酚，在肺部具有抗炎特性，其作用部分通过诱导 Sirtuin（SIRT）1 活性来介导。我们评估了葡萄酒和白藜芦醇的摄入量以及 SIRT1 单核苷酸多态性（SNP）对一般人群肺功能的影响。在基于人群的多滕坎姆（Doetinchem）队列（n=3224）中，分析了红葡萄酒和白葡萄酒以及白藜芦醇摄入对 1 秒用力呼气量（FEV1）、用力肺活量（FVC）和 FEV1/FVC 的影响。在多滕坎姆（n=1152）和弗拉格特韦德-弗拉伦丹（n=1390）队列中分析了四个标记 SIRT1 SNP 与肺功能的关系。白藜芦醇的摄入量与更高的 FVC 水平相关，而白葡萄酒的摄入量与更高的 FEV1 水平和气道阻塞的风险降低相关。SIRT1 SNP 与肺功能的水平或病程没有显著的直接或间接关联，无论是通过葡萄酒或白藜芦醇的摄入。这项研究表明，白藜芦醇的摄入量与一般人群的肺功能呈正相关，证实了先前报道的白葡萄酒摄入量与较高的 FEV1 水平之间的正相关关系，并显示与较高的 FEV1/FVC 比值有关。这些影响可能不是通过 SIRT1 中的 SNP 产生的。
