Hussain A, Mohanty S B
Arch Virol. 1979;59(1-2):17-24. doi: 10.1007/BF01317890.
Calves experimentally infected with bovine rhinovirus type 1 developed a mild respiratory disease and exhibited a cell mediated immune (CMI) response, as determined by leukocyte migration inhibition (LMI) and lymphocyte blastogenesis tests. The CMI response to the virus was detected by day 3 post-inoculation using direct and indirect LMI tests. It persisted through day 28, with maximal responses occurring between days 4 and 14. Measurement of cellular immunity by blast transformation, however, was not evidenced until day 12. The humoral antibody response was minimal with serum neutralizing titers ranging from 1:4 to 1:16 and this response was not evident until 3 weeks after inoculation.
通过实验感染1型牛鼻病毒的小牛出现了轻度呼吸道疾病，并表现出细胞介导免疫（CMI）反应，这是通过白细胞迁移抑制（LMI）和淋巴细胞增殖试验确定的。接种后第3天，使用直接和间接LMI试验检测到对该病毒的CMI反应。该反应持续到第28天，在第4天至第14天之间出现最大反应。然而，直到第12天才通过增殖转化证明有细胞免疫。体液抗体反应很微弱，血清中和滴度在1:4至1:16之间，并且直到接种后3周才出现这种反应。
