Davies H A, Macnaughton M R
Arch Virol. 1979;59(1-2):25-33. doi: 10.1007/BF01317891.
The morphology of three coronaviruses, avian infectious bronchitis virus strain Connecticut (IBV Conn), human coronavirus strain 229E (HCV 229E) and mouse hepatitis virus strain 3 (MHV3), were examined by negative staining. Significant differences were found in the sizes of the three coronaviruses. Furthermore, three types of surface projection of the same lengths, but varying widths and morphology, were observed. Both IBV Conn and HCV 229E had bulbous projections characteristic of coronaviruses, although the projections of HCV 229E were somewhat thinner than those of IBV Conn. On the other hand, MHV3 particles had thin, cone-shaped surface projections, that were completely unlike typical coronavirus projections. The significance of these results is discussed.
通过负染色法对三种冠状病毒,即禽传染性支气管炎病毒康涅狄格株(IBV Conn)、人冠状病毒229E株(HCV 229E)和小鼠肝炎病毒3株(MHV3)的形态进行了检查。发现这三种冠状病毒的大小存在显著差异。此外,还观察到三种长度相同但宽度和形态各异的表面突起。IBV Conn和HCV 229E都具有冠状病毒特有的球状突起,尽管HCV 229E的突起比IBV Conn的突起稍细。另一方面,MHV3颗粒具有薄的、锥形的表面突起,这与典型的冠状病毒突起完全不同。讨论了这些结果的意义。