MRC Centre of Epidemiology for Child Health, Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Atherosclerosis. 2011 Nov;219(1):361-7. doi: 10.1016/j.atherosclerosis.2011.07.109. Epub 2011 Jul 30.
To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity.
Data from the 1958 British birth cohort (n=7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45 y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45 y.
Activity at different ages was associated with HDL-cholesterol and triglycerides at 45 y: e.g. in men, a 1 day/week greater activity frequency at 42 y was associated with 0.006 mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33 y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45 y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1 h/day greater sitting among men was associated with a 0.012 mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04 mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45 y, attenuated, respectively, to 0.03 mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent.
Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI.
探讨不同生命阶段的身体（活动）与中年时血脂的关系，同时检验肥胖等潜在混杂和中介因素的作用。
本研究使用来自 1958 年英国出生队列（n=7824）的数据，采用线性回归分析前瞻性报告的活动频率和看电视时间（23、33、42 和 45 岁）与 45 岁时总胆固醇、LDL-胆固醇、HDL-胆固醇和甘油三酯的关系。
不同年龄的活动与 45 岁时的 HDL-胆固醇和甘油三酯有关：例如，男性在 42 岁时每周多活动一天，HDL-胆固醇升高 0.006mmol/L，甘油三酯降低 1.4%。大多数关联在调整了协变量（生活方式和社会经济因素）后减弱，但并未完全消除：例如，在男性中，33 岁时每周多活动一天，估计甘油三酯降低 2.0%，调整后降低到 1.8%。不过，在女性中，而不是男性中，23 岁和 45 岁的活动都与 HDL-胆固醇呈累积效应。对于久坐行为，与工作时的坐姿有关：男性每天多坐 1 小时，调整协变量后，HDL-胆固醇降低 0.012mmol/L。看电视的时间也与 HDL-胆固醇有关：例如，在男性中，45 岁时每天看电视时间增加 0.04mmol/L，HDL-胆固醇降低 5.9%，调整协变量后，分别降低到 0.03mmol/L 和 4.6%。进一步调整当前 BMI 后，关联进一步减弱。总胆固醇和 LDL-胆固醇的相关性则不太一致。
不同成年年龄的活动和久坐行为与中年时的 HDL-胆固醇和甘油三酯有关。这些关联部分由其他生活方式因素和 BMI 介导。
