通过 DNA 机器将动力学接枝的 G-四链体与 DNA 纳米结构结合，用于结构和功能编码。
Kinetically grafting G-quadruplexes onto DNA nanostructures for structure and function encoding via a DNA machine.
机构信息
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, China.
出版信息
Chem Commun (Camb). 2011 Oct 14;47(38):10563-5. doi: 10.1039/c1cc13973h. Epub 2011 Aug 22.
PMID:21858307
Abstract
Kinetically grafting G-quadruplexes onto one-dimensional DNA nanostructures with precise positioning was realized in this study. The programs hold great promise for label-free and enzyme-free detection of various targets as a result of signal amplification from G-quadruplexes, and building DNA nanostructures as scaffolds due to the molecular recognition capacity of G-quadruplex aptamers.
摘要
本研究实现了动力学地将 G-四链体接枝到具有精确定位的一维 DNA 纳米结构上。由于 G-四链体的信号放大，以及 G-四链体适体的分子识别能力作为支架构建 DNA 纳米结构，这些方案有望实现各种目标的无标记和无酶检测。
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