Center for Environmental Research and Children’s Health, School of Public Health, University of California, Berkeley, Berkeley, CA 94704, USA.
Am J Epidemiol. 2011 Oct 15;174(8):885-92. doi: 10.1093/aje/kwr212. Epub 2011 Aug 30.
Polybrominated diphenyl ethers (PBDEs) are a class of persistent compounds that have been used as flame retardants in vehicles, household furnishings, and consumer electronics. This study examined whether concentrations of PBDEs in maternal serum during pregnancy were associated with infant birth weight, length, head circumference, and length of gestation. Participants were pregnant women (n = 286) enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) Study, a longitudinal cohort study of low-income, predominantly Mexican families living in the Salinas Valley, California. Blood samples were collected near the 26th week of pregnancy in 1999-2000, and concentrations of 10 PBDE congeners (BDE-17, -28, -47, -66, -85, -99, -100, -153, -154, and -183) were measured. Multiple linear regression models were used to investigate the association of lipid-adjusted, log(10)-transformed PBDE concentrations and birth outcome. In adjusted analyses, negative associations with birth weight were seen with BDE-47 (β = -115 g, 95% confidence interval (CI): -229, -2), BDE-99 (β = -114 g, 95% CI: -225, -4), and BDE-100 (β = -122 g, 95% CI: -235, -9). These findings were diminished slightly and were no longer statistically significant when maternal weight gain was included in the models. PBDE congeners were not associated with birth length, head circumference, or gestational duration.
多溴二苯醚（PBDEs）是一类持久性化合物，曾被用作车辆、家庭用品和消费电子产品中的阻燃剂。本研究旨在探讨孕妇妊娠期间血清中多溴二苯醚的浓度是否与婴儿出生体重、身长、头围和妊娠期有关。研究对象为 1999-2000 年参加萨利纳斯母婴健康评估中心（CHAMACOS）研究的 286 名孕妇，该研究为一项针对生活在加利福尼亚州萨利纳斯谷的低收入、以墨西哥裔为主的家庭的纵向队列研究。1999-2000 年，在妊娠 26 周左右采集了血样，并测量了 10 种多溴二苯醚同系物（BDE-17、-28、-47、-66、-85、-99、-100、-153、-154 和-183）的浓度。采用多元线性回归模型来探讨经脂质调整的、以对数值转换的多溴二苯醚浓度与出生结局的相关性。在调整分析中，BDE-47（β=-115g，95%置信区间（CI）：-229，-2）、BDE-99（β=-114g，95%CI：-225，-4）和 BDE-100（β=-122g，95%CI：-235，-9）与出生体重呈负相关。当将母体体重增加纳入模型后，这些相关性略有减弱且不再具有统计学意义。多溴二苯醚同系物与出生长度、头围或妊娠期无相关性。
