Department of Electronics, School of Information Science and Technology, Sun Yat-Sen University, Guangzhou 510006, China.
Nucleic Acids Res. 2012 Jan;40(1):27-36. doi: 10.1093/nar/gkr689. Epub 2011 Aug 31.
Eukaryotic chromosomes are not randomly distributed in the interphase nucleus, but instead occupy distinct territories. Nonetheless, the genome-wide relationships of gene regulation to gene nuclear location remain poorly understood in yeast. In the three-dimensional view of gene regulation, we found that a considerable number of transcription factors (TFs) regulate genes that are colocalized in the nucleus. Colocalized TF target genes are more strongly coregulated compared with the other TF target genes. Target genes of chromatin regulators are also colocalized. These results demonstrate that colocalization of coregulated genes is a common process, and three-dimensional gene positioning is an important part of gene regulation. Our findings will have implications in understanding nuclear architecture and function.
真核生物染色体在间期细胞核中并非随机分布，而是占据特定的区域。然而，在酵母中，基因调控与基因核定位之间的全基因组关系仍知之甚少。在基因调控的三维视图中，我们发现相当数量的转录因子（TFs）调节在核内共定位的基因。与其他 TF 靶基因相比，共定位 TF 靶基因的共调控更为强烈。染色质调节因子的靶基因也发生共定位。这些结果表明，共调控基因的共定位是一个普遍的过程，三维基因定位是基因调控的重要组成部分。我们的发现将有助于理解核结构和功能。
