First Propedeutic Surgical Clinic, Aristotle's University of Thessaloniki, AHEPA Hospital, St Kyriakidi 1, 54636 Thessaloniki, Greece.
Tech Coloproctol. 2011 Oct;15 Suppl 1:S107-10. doi: 10.1007/s10151-011-0744-y.
Colorectal cancer (CRC) is a major cause of death in the western world and a leading cause of cancer-related death. It is one of the most common human malignancies with >300,000 cases both in the United States and in the European Union each year. The present study was conducted to assess differences in various variables of CRC, such as location of the tumor, differentiation, Dukes classification, 5-year survival and possible changes in these patterns during the examined period.
We collected data on 2000 patients with colorectal cancer, diagnosed and treated from 1960 to 2008 in 1st Propedeutic Surgical Clinic of Aristotle's University, Thessaloniki.
Of 2000 cases reviewed, cancer was almost equal presented to both sexes, for all groups. Rectum was the most common tumor location in all analyzed groups (40.1%). The most common tumor differentiation was the moderate one (68.5%). Concerning tumor staging, Dukes' B tumors were most common (42.5%), and the cancer-related 5-year survival was increased by the time from 42 to 71%.
In the past 20 years, considerable improvements have been made in colorectal cancer therapy, and patients had received more sophisticated and multidisciplinary treatments, resulting in a better 5-year survival rate.
结直肠癌（CRC）是西方国家主要的死亡原因，也是癌症相关死亡的主要原因。它是最常见的人类恶性肿瘤之一，每年在美国和欧盟都有超过 30 万例病例。本研究旨在评估 CRC 的各种变量（如肿瘤位置、分化、Dukes 分类、5 年生存率以及在此期间这些模式的可能变化）的差异。
我们收集了 2000 例在 1960 年至 2008 年期间在塞萨洛尼基亚里士多德大学第一外科学诊所诊断和治疗的结直肠癌患者的数据。
在所审查的 2000 例病例中，所有组中癌症在两性中几乎相等。直肠是所有分析组中最常见的肿瘤位置（40.1%）。最常见的肿瘤分化是中度分化（68.5%）。关于肿瘤分期，Dukes'B 期肿瘤最常见（42.5%），癌症相关的 5 年生存率随着时间的推移从 42%增加到 71%。
在过去的 20 年中，结直肠癌的治疗取得了相当大的进展，患者接受了更复杂和多学科的治疗，导致 5 年生存率提高。
