Agbenorku Pius, Agbenorku Margaret, Iddi Abiba, Abude Fritz, Sefenu Ransford, Matondo Paul, Schneider William
Eur J Plast Surg. 2011 Aug;34(4):267-272. doi: 10.1007/s00238-010-0513-6. Epub 2010 Sep 25.
The previous study in Wudoaba villages suggested that cleft lip and cleft palate (CL/CP) may be endemic in the Wudoaba cluster of villages in the Ketu South District of the Volta Region in South East Ghana. The study was to detect the prevalence of CL/CP in the Wudoaba communities and to investigate the factors associated with the causes of this malformation in the area. Two different interview-based questionnaires were designed to collect data over a period of 3 days from March 27 to 29, 2006. A purposive and accidental random sampling technique was used in the administering of the various questionnaires to the respondents. Data collected were recorded and analyzed with SPSS version 17.0. A total 99 respondents, with a mean age of 55.0 years, were interviewed. Out of it, 57.6% (n = 57) were related to their spouses: 54 first cousins and three other family relations. The prevalence of CL/CP is at least 6.3 per 1,000 people (i.e., 25/4,000). Majority (56.0%, n = 14) of the cleft cases were unilateral. Interviews revealed that genetic homogeneity and vitamin deficiencies in this community may be a causal factor for the high prevalence of CL/CP. This community provides clues suggesting that the magnitude of CL/CP may be larger than other studies and identifies the Wudoaba population as one that could be further studied to explore the underlying factors causing this congenital malformation.
此前在武多阿巴村开展的研究表明，唇腭裂（CL/CP）在加纳东南部沃尔特地区凯图南区的武多阿巴村群中可能呈地方性流行。该研究旨在检测武多阿巴社区中唇腭裂的患病率，并调查该地区与这种畸形病因相关的因素。设计了两份不同的基于访谈的问卷，在2006年3月27日至29日的3天时间里收集数据。在向受访者发放各种问卷时，采用了立意抽样和偶遇随机抽样技术。收集到的数据用SPSS 17.0版本进行记录和分析。总共采访了99名受访者，平均年龄为55.0岁。其中，57.6%（n = 57）与他们的配偶有亲属关系：54对是第一代堂表亲，另外还有三对是其他亲属关系。唇腭裂的患病率至少为每1000人中有6.3例（即25/4000）。大多数（56.0%，n = 14）腭裂病例为单侧。访谈显示，该社区的基因同质性和维生素缺乏可能是唇腭裂高患病率的一个致病因素。这个社区提供了线索，表明唇腭裂的发病率可能比其他研究的结果更高，并确定武多阿巴人群是一个值得进一步研究以探索导致这种先天性畸形潜在因素的群体。
