Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
Exp Biol Med (Maywood). 2011 Oct;236(10):1205-10. doi: 10.1258/ebm.2011.011031. Epub 2011 Sep 5.
Recent studies indicated that regular consumption of antioxidant-rich foods reduces cellular oxidative stress and protects against health-related problems. This study aimed to assess the in vitro antioxidant properties of the papaya epicarp extract against hydrogen peroxide (H(2)O(2))-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that papaya epicarp extract acted as a potent free radical scavenger and provided neuroprotection against H(2)O(2)-induced oxidative stress. Papaya epicarp extract ameliorated glutathione depletion, restored total antioxidant capacity and augmented the inhibition of antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). In conclusion, papaya epicarp extract can be used as a functional dietary ingredient that might help in reducing the neurological health problems associated with various oxidative stress insults.
最近的研究表明，经常食用富含抗氧化剂的食物可以减少细胞氧化应激，预防与健康有关的问题。本研究旨在评估木瓜果皮提取物对人 SH-SY5Y 神经元细胞过氧化氢 (H2O2) 诱导的氧化应激的体外抗氧化特性。我们的研究表明，木瓜果皮提取物是一种有效的自由基清除剂，可以提供神经保护作用，防止 H2O2 诱导的氧化应激。木瓜果皮提取物改善了谷胱甘肽的耗竭，恢复了总抗氧化能力，并增强了抗氧化酶（过氧化氢酶、谷胱甘肽过氧化物酶和超氧化物歧化酶）的抑制作用。总之，木瓜果皮提取物可用作一种功能性的膳食成分，有助于减轻与各种氧化应激损伤相关的神经健康问题。
