Kim Ki Hyun, Choi Sang Un, Kim Chung Sub, Lee Kang Ro
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Biosci Biotechnol Biochem. 2012;76(4):825-7. doi: 10.1271/bbb.110751. Epub 2012 Apr 7.
A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC(50) values of 7.41, 9.20, 4.53, and 12.91 µM).
从朝鲜小檗的树干中分离出一种新的甾体化合物itesmol 3 - O - 棕榈酸酯（1）以及两种已知的甾体化合物。通过二维核磁共振等光谱分析和化学反应确定了化合物1的结构。化合物1对A549、SK - OV - 3、SK - MEL - 2和HCT - 15细胞系表现出潜在的抗增殖活性（各自的半数抑制浓度IC(50)值分别为7.41、9.20、4.53和12.91 μM）。
