来自朝鲜小檗树干的细胞毒性甾体
Cytotoxic steroids from the trunk of Berberis koreana.
作者信息
Kim Ki Hyun, Choi Sang Un, Kim Chung Sub, Lee Kang Ro
机构信息
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
出版信息
Biosci Biotechnol Biochem. 2012;76(4):825-7. doi: 10.1271/bbb.110751. Epub 2012 Apr 7.
A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC(50) values of 7.41, 9.20, 4.53, and 12.91 µM).
从朝鲜小檗的树干中分离出一种新的甾体化合物itesmol 3 - O - 棕榈酸酯（1）以及两种已知的甾体化合物。通过二维核磁共振等光谱分析和化学反应确定了化合物1的结构。化合物1对A549、SK - OV - 3、SK - MEL - 2和HCT - 15细胞系表现出潜在的抗增殖活性（各自的半数抑制浓度IC(50)值分别为7.41、9.20、4.53和12.91 μM）。
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