椎间盘退变的生物力学
Biomechanics of intervertebral disk degeneration.
作者信息
Inoue Nozomu, Espinoza Orías Alejandro A
机构信息
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
出版信息
Orthop Clin North Am. 2011 Oct;42(4):487-99, vii. doi: 10.1016/j.ocl.2011.07.001.
Abstract
Degenerative changes in the material properties of nucleus pulposus and anulus fibrosus promote changes in viscoelastic properties of the whole disc. Volume, pressure and hydration loss in the nucleus pulposus, disk height decreases and fissures in the anulus fibrosus, are some of the signs of the degenerative cascade that advances with age and affect, among others, spinal function and its stability. Much remains to be learned about how these changes affect the function of the motion segment and relate to symptoms such as low back pain and altered spinal biomechanics.
摘要
髓核和纤维环材料特性的退行性变化会促使整个椎间盘的粘弹性特性发生改变。髓核的体积、压力和含水量降低，椎间盘高度减小以及纤维环出现裂隙，这些都是随着年龄增长而出现的退行性级联反应的一些迹象，会影响脊柱功能及其稳定性等。关于这些变化如何影响运动节段的功能以及与腰背痛和脊柱生物力学改变等症状的关系，仍有许多有待了解的地方。
相似文献
1
Biomechanics of intervertebral disk degeneration.椎间盘退变的生物力学
Orthop Clin North Am. 2011 Oct;42(4):487-99, vii. doi: 10.1016/j.ocl.2011.07.001.
2
Fundamentals of Intervertebral Disc Degeneration.椎间盘退变基础
World Neurosurg. 2022 Jan;157:264-273. doi: 10.1016/j.wneu.2021.09.066.
3
Low Back Pain: A Biomechanical Rationale Based on "Patterns" of Disc Degeneration.下背痛：基于椎间盘退变“模式”的生物力学原理
Spine (Phila Pa 1976). 2015 Aug 1;40(15):1165-72. doi: 10.1097/BRS.0000000000000982.
4
[Biomechanics of the intervertebral disc : Consequences of degenerative changes].[椎间盘的生物力学：退变改变的后果]
Orthopadie (Heidelb). 2024 Dec;53(12):912-917. doi: 10.1007/s00132-024-04578-4. Epub 2024 Nov 5.
5
The mechanical response of the lumbar spine to different combinations of disc degenerative changes investigated using randomized poroelastic finite element models.采用随机多孔弹性有限元模型研究不同椎间盘退变组合对腰椎机械反应的影响。
Eur Spine J. 2011 Apr;20(4):563-71. doi: 10.1007/s00586-010-1586-4. Epub 2010 Oct 10.
6
A Brief Review of the Degenerative Intervertebral Disc Disease.椎间盘退变疾病的简要综述
Med Arch. 2019 Dec;73(6):421-424. doi: 10.5455/medarh.2019.73.421-424.
7
Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration.椎间盘退变过程中纤维环和髓核中蛋白聚糖的mRNA和蛋白质水平变化。
Spine (Phila Pa 1976). 2002 Oct 15;27(20):2212-9. doi: 10.1097/00007632-200210150-00006.
8
Accumulated Spinal Axial Biomechanical Loading Induces Degeneration in Intervertebral Disc of Mice Lumbar Spine.累积的脊柱轴向生物力学负荷诱导小鼠腰椎间盘退变。
Orthop Surg. 2018 Feb;10(1):56-63. doi: 10.1111/os.12365. Epub 2018 Feb 12.
9
Developing a mechanical and chemical model of degeneration in young bovine lumbar intervertebral disks and reversing loss in mechanical function.建立年轻牛腰椎间盘退变的力学和化学模型并逆转其力学功能丧失。
J Spinal Disord Tech. 2014 Jul;27(5):E168-75. doi: 10.1097/BSD.0000000000000085.
10
Structure and biology of the intervertebral disk in health and disease.健康与疾病状态下椎间盘的结构与生物学特性
Orthop Clin North Am. 2011 Oct;42(4):447-64, vii. doi: 10.1016/j.ocl.2011.07.012.
引用本文的文献
1
Short-Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One-Strike Trigger.培养的牛尾椎间盘短期动态卸载可部分减轻单次触发诱导的退变。
JOR Spine. 2025 Jul 16;8(3):e70092. doi: 10.1002/jsp2.70092. eCollection 2025 Sep.
2
Evaluation of lumbar intervertebral disc degeneration using Na-MRI in clinical settings.在临床环境中使用钠磁共振成像评估腰椎间盘退变。
Skeletal Radiol. 2025 Jun 16. doi: 10.1007/s00256-025-04968-5.
3
Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology.与细胞外基质结合的水和离子驱动应力松弛，有助于MRI检测与肿胀相关的病变。
Nat Biomed Eng. 2025 May;9(5):772-786. doi: 10.1038/s41551-025-01369-w. Epub 2025 Apr 15.
4
Biomechanical Evaluation of Cervical Interbody Fusion Cages for Anterior Cervical Discectomy and Fusion With Variations in Morphology: A Finite Element Analysis.颈椎前路椎间盘切除融合术中不同形态颈椎椎间融合器的生物力学评估：有限元分析
Biomed Eng Comput Biol. 2025 Mar 17;16:11795972251321307. doi: 10.1177/11795972251321307. eCollection 2025.
5
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics: Obstacles and Potential Breakthrough Technologies.椎间盘退变与再生：新的分子机制与治疗方法：障碍与潜在的突破性技术
Cells. 2024 Dec 19;13(24):2103. doi: 10.3390/cells13242103.
6
Low Back Pain During and After Spaceflight: A Systematic Review with Meta-Analysis.太空飞行期间及之后的腰痛：一项系统评价与荟萃分析
J Pain Res. 2024 Dec 6;17:4103-4139. doi: 10.2147/JPR.S491060. eCollection 2024.
7
Mechanical Characterization of Non-degraded Porcine Annulus Fibrosus Material Properties.未降解猪纤维环材料特性的力学表征
Ann Biomed Eng. 2024 Nov 5. doi: 10.1007/s10439-024-03629-3.
8
A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration.一种用于研究与压缩相关的慢性椎间盘退变的重复冲击加载器官培养模型。
Biomol Biomed. 2025 Jan 30;25(3):708-719. doi: 10.17305/bb.2024.10640.
9
The impact of disc degeneration on the dynamic characteristics of the lumbar spine: a finite element analysis.椎间盘退变对腰椎动态特性的影响：有限元分析
Front Bioeng Biotechnol. 2024 May 1;12:1384187. doi: 10.3389/fbioe.2024.1384187. eCollection 2024.
10
microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3.微小 RNA-365 通过靶向 EFNA3 调节髓核细胞凋亡和细胞外基质降解来减轻椎间盘退变。
J Cell Mol Med. 2024 Jan;28(2):e18054. doi: 10.1111/jcmm.18054. Epub 2023 Nov 27.
本文引用的文献
1
A detailed microscopic examination of alterations in normal anular structure induced by mechanical destabilization in an ovine model of disc degeneration.一种详细的微观检查，研究在羊椎间盘退变模型中机械失稳引起的正常环状结构改变。
Spine (Phila Pa 1976). 2010 Oct 15;35(22):1965-73. doi: 10.1097/BRS.0b013e3181e0f085.
2
The mechanical response of the lumbar spine to different combinations of disc degenerative changes investigated using randomized poroelastic finite element models.采用随机多孔弹性有限元模型研究不同椎间盘退变组合对腰椎机械反应的影响。
Eur Spine J. 2011 Apr;20(4):563-71. doi: 10.1007/s00586-010-1586-4. Epub 2010 Oct 10.
3
Effects of torsion on intervertebral disc gene expression and biomechanics, using a rat tail model.利用大鼠尾模型研究扭转对椎间盘基因表达和生物力学的影响。
Spine (Phila Pa 1976). 2011 Apr 15;36(8):607-14. doi: 10.1097/BRS.0b013e3181d9b58b.
4
How age influences unravelling morphology of annular lamellae - a study of interfibre cohesivity in the lumbar disc.年龄如何影响环状薄片的形态解析 - 腰椎间盘内纤维间内聚力的研究。
J Anat. 2010 Mar;216(3):310-9. doi: 10.1111/j.1469-7580.2009.01197.x.
5
Innervation of anulus tears: an experimental animal study.纤维环撕裂的神经支配：一项实验动物研究。
Spine (Phila Pa 1976). 2010 May 20;35(12):1200-5. doi: 10.1097/BRS.0b013e3181c02812.
6
The influence of torsion on disc herniation when combined with flexion.扭转对合并屈曲时椎间盘突出的影响。
Eur Spine J. 2010 Sep;19(9):1468-78. doi: 10.1007/s00586-010-1383-0. Epub 2010 May 1.
7
Non-linearity of flexion-extension characteristics in spinal segments.脊柱节段屈伸特性的非线性
Acta Bioeng Biomech. 2009;11(4):3-8.
8
Response analysis of the lumbar spine during regular daily activities--a finite element analysis.常规日常活动中腰椎的反应分析——有限元分析。
J Biomech. 2010 Jul 20;43(10):1849-56. doi: 10.1016/j.jbiomech.2010.03.035. Epub 2010 Apr 14.
9
Theoretical and uniaxial experimental evaluation of human annulus fibrosus degeneration.人纤维环退变的理论与单轴实验评估
J Biomech Eng. 2009 Nov;131(11):111007. doi: 10.1115/1.3212104.
10
A biochemical/biophysical 3D FE intervertebral disc model.一个生物化学/生物物理学的 3D 有限元椎间盘模型。
Biomech Model Mechanobiol. 2010 Oct;9(5):641-50. doi: 10.1007/s10237-010-0203-0. Epub 2010 Mar 13.
Zotero 插件