Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, UK.
Eur J Immunol. 2011 Sep;41(9):2494-8. doi: 10.1002/eji.201141714.
Interest in intestinal mononuclear phagocytes (MPs), both DCs and macrophages (Mφs), has exploded in the recent years. In this Viewpoint we will detail how resident intestinal lamina propria (LP) Mφs possess distinctive properties that reflect adaptation to a unique microenvironment. They play quite different roles in the normal and inflamed mucosa and, as we will show, the existing paradigms of differentiated Mφ subsets and of 'resident' versus 'inflammatory' monocytes based on other tissues may not apply to the gut. Strategies for targeting Mφs as a means of dampening intestinal inflammation will need to take account of these unique characteristics.
近年来，人们对肠道单核吞噬细胞（MPs），包括树突状细胞（DC）和巨噬细胞（Mφ）的兴趣大增。在本观点中，我们将详细介绍驻留于肠道固有层（LP）的巨噬细胞（Mφ）如何具有独特的特性，这些特性反映了它们对独特微环境的适应。它们在正常和炎症黏膜中发挥着截然不同的作用，正如我们将展示的那样，基于其他组织的分化巨噬细胞亚群和“常驻”与“炎症”单核细胞的现有范例可能不适用于肠道。作为抑制肠道炎症的一种手段，靶向 Mφ 的策略需要考虑到这些独特的特征。
