Department of Obstetrics and Gynecology, University of Miami, Miami, FL, USA.
Am J Obstet Gynecol. 2011 Oct;205(4 Suppl):S4-8. doi: 10.1016/j.ajog.2011.06.056.
In the 50 years since the advent of combined oral contraceptives the amount of estrogen in oral contraceptives dropped from over 100 mcg to less than 30 mcg. Many noncontraceptive health benefits have emerged that decrease mortality and improve quality of life. Some of the immediate benefits include improvement of menorrhagia and dysmenorrhea, reduction in premenstrual dysphoric disorder symptoms, and decreased acne. As an effective birth control method oral contraceptives also decrease pregnancy-related deaths by preventing pregnancy. After the reproductive years, previous use of oral contraceptives continues to be beneficial, reducing the risk of death from ovarian and endometrial cancer. All these benefits have held up over time whereas cardiovascular risks have lessened because of the decrease in oral contraceptive pill dosage. Decreased ovarian cyst formation is an example of benefit with higher-dose oral contraceptive formulations that no longer holds true with low-dose pills.
自复方口服避孕药问世以来的 50 年间,避孕药中的雌激素含量已从超过 100 微克降至不足 30 微克。许多非避孕的健康益处已经显现,降低了死亡率并提高了生活质量。一些直接的益处包括改善月经过多和痛经,减轻经前烦躁障碍症状,以及减少痤疮。作为一种有效的避孕方法,口服避孕药还通过预防怀孕来降低与怀孕相关的死亡风险。在生育期过后,之前使用口服避孕药仍有好处,可以降低卵巢癌和子宫内膜癌的死亡风险。所有这些益处都随着时间的推移而保持不变,而心血管风险因口服避孕药剂量减少而减轻。卵巢囊肿形成减少就是一个例子,在高剂量口服避孕药制剂中存在这种益处,但在低剂量药物中不再如此。