Centre Hospitalier de Versailles, Service de Pédopsychiatrie, Le Chesnay, France and EA40/47 UVSQ, France.
BMC Psychiatry. 2011 Sep 30;11:158. doi: 10.1186/1471-244X-11-158.
The aims of this study were to assess the prevalence of a comorbid Attention Deficit Hyperactivity Disorder (ADHD) diagnosis in Borderline Personality Disorder (BPD), and its impact on the clinical presentation of BPD in adolescents, and to determine which type of impulsivity specifically characterizes adolescents with BPD-ADHD.
ADHD diagnoses were sought in a sample of 85 DSM-IV BPD adolescents drawn from the EURNET BPD. Axis-I and -II disorders were determined with the K-SADS-PL and the SIDP-IV, respectively. Impulsivity was assessed with the BIS-11.
11% (N = 9) of BPD participants had a current ADHD diagnosis. BPD-ADHD adolescents showed higher prevalence of Disruptive disorders (Chi2 = 9.09, p = 0.01) and a non-significant trend for a higher prevalence of other cluster B personality disorders (Chi2 = 2.70, p = 0.08). Regression analyses revealed a significant association between Attentional/Cognitive impulsivity scores and ADHD (Wald Z = 6.69; p = 0.01; Exp(B) = 2.02, CI 95% 1.19-3.45).
Comorbid ADHD influences the clinical presentation of adolescents with BPD and is associated with higher rates of disruptive disorders, with a trend towards a greater likelihood of cluster B personality disorders and with higher levels of impulsivity, especially of the attentional/cognitive type. A subgroup of BPD patients may exhibit developmentally driven impairments of the inhibitory system persisting since childhood. Specific interventions should be recommended for this subsample of BPD adolescents.
本研究旨在评估边缘型人格障碍(BPD)中合并注意缺陷多动障碍(ADHD)诊断的患病率,及其对青少年 BPD 临床表现的影响,并确定哪种冲动特质具体特征化了 ADHD 共病 BPD 的青少年。
在从 EURNET BPD 中抽取的 85 名 DSM-IV BPD 青少年样本中寻找 ADHD 诊断。使用 K-SADS-PL 和 SIDP-IV 分别确定轴 I 和轴 II 障碍。使用 BIS-11 评估冲动性。
11%(N=9)的 BPD 参与者有当前的 ADHD 诊断。BPD-ADHD 青少年表现出更高的破坏性行为障碍患病率(卡方=9.09,p=0.01),且其他 B 群人格障碍的患病率有更高的非显著趋势(卡方=2.70,p=0.08)。回归分析显示,注意力/认知冲动性评分与 ADHD 之间存在显著关联(Wald Z=6.69;p=0.01;Exp(B)=2.02,95%CI 1.19-3.45)。
共患 ADHD 影响了 BPD 青少年的临床表现,与更高的破坏性行为障碍发生率相关,与 B 群人格障碍更可能发生的趋势相关,与更高水平的冲动性相关,特别是注意力/认知型冲动性。BPD 患者的一个亚组可能表现出自童年以来持续存在的抑制系统发育驱动损伤。应向这组 ADHD 共病 BPD 青少年推荐特定的干预措施。