Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, No. 1 Dongjiao Min Xiang, Dongcheng District, Beijing, 100730, China.
Graefes Arch Clin Exp Ophthalmol. 2012 May;250(5):741-9. doi: 10.1007/s00417-011-1824-4. Epub 2011 Oct 5.
To identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber.
The study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photography of both eyes. Trained graders assessed the presence of AMD lesions. Arteriolar and venular diameters were measured with a specific computer-assisted program and were summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE).
The data for the 199 individuals with evaluable retinal photographs and early AMD and 400 age-matched individuals randomly selected from the group without AMD were analyzed. After adjusting for participants' age, sex, smoking status, hypertension, diabetes, BMI, and CRVE, the multivariate adjusted model showed that a higher CRAE was significantly associated with early AMD (OR = 1.34; 95% CI: 1.05-1.71; p = 0.020) and the presence of soft distinct drusen (OR = 1.32 (95% CI: 1.02-1.71, p = 0.037). There were no significant associations between CRVE and early AMD.
Dilated retinal arteriolar caliber is associated with early AMD and soft distinct drusen in this population. We found no significant associations between CRAE and other characteristics of the retina related to AMD or between retinal venal caliber and early AMD. More research is needed to determine whether the difference between these results and those previously published stem from the rural living conditions of the participants or other factors.
本研究旨在探讨中国农村人群中与年龄相关性黄斑变性（AMD）相关的因素，重点在于视网膜血管口径。
研究人群包括邯郸眼病研究的 6830 名参与者。所有参与者均接受双眼数字视网膜摄影。经过培训的分级员评估 AMD 病变的存在。采用特定的计算机辅助程序测量动脉和静脉直径，并将其总结为中心视网膜小动脉等效直径（CRAE）和中心视网膜静脉等效直径（CRVE）。
对可评估视网膜照片和早期 AMD 的 199 名患者以及从无 AMD 组中随机选择的 400 名年龄匹配的个体的数据进行了分析。在校正了参与者的年龄、性别、吸烟状况、高血压、糖尿病、BMI 和 CRVE 后，多变量调整模型显示，较高的 CRAE 与早期 AMD（OR=1.34；95%CI：1.05-1.71；p=0.020）和软性明确玻璃膜疣（OR=1.32（95%CI：1.02-1.71，p=0.037）显著相关。CRVE 与早期 AMD 之间无显著相关性。
在该人群中，扩张的视网膜小动脉口径与早期 AMD 和软性明确玻璃膜疣相关。我们发现 CRAE 与 AMD 相关的其他视网膜特征或视网膜静脉口径与早期 AMD 之间无显著相关性。需要进一步研究以确定这些结果与之前发表的结果之间的差异是否源于参与者的农村生活条件或其他因素。
