FtsA蛋白的高水平表达抑制大肠杆菌K-12中的细胞分裂。
High-level expression of the FtsA protein inhibits cell septation in Escherichia coli K-12.
作者信息
Wang H C, Gayda R C
机构信息
Department of Microbiology, Louisiana State University, Baton Rouge.
出版信息
J Bacteriol. 1990 Aug;172(8):4736-40. doi: 10.1128/jb.172.8.4736-4740.1990.
Abstract
DNA fragments encoding the ftsA gene were subcloned into plasmids downstream of a lac promoter or a tac promoter. These plasmid constructs, when transformed into wild-type and mutant strains, inhibited normal cell septation, causing the formation of long nonseptate filaments. This phenotype is due to overproduction of the FtsA protein.
摘要
编码ftsA基因的DNA片段被亚克隆到位于lac启动子或tac启动子下游的质粒中。当将这些质粒构建体转化到野生型和突变菌株中时，会抑制正常的细胞分裂，导致形成长的无隔膜丝状体。这种表型是由于FtsA蛋白的过量产生所致。
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