Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA; E-Mail:
Viruses. 2010 Nov;2(11):2436-42. doi: 10.3390/v2112436. Epub 2010 Nov 5.
Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory [1] gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.
正链 RNA（+RNA）病毒通过颠覆宿主蛋白和膜，并在感染过程中改变细胞途径来利用宿主细胞机制。为了实现稳健的复制，一些+RNA 病毒，如脊髓灰质炎病毒（PV），会构建特殊的细胞内隔室，称为病毒复制细胞器。Altan-Bonnett 实验室的一项最新研究[1]深入了解了脊髓灰质炎病毒复制细胞器的形成，这些独特的亚细胞结构由于动态细胞膜重塑而包含许多单个复制复合物。
