健康 22 岁战斗伤员的侵袭性毛霉病和曲霉菌病：病例报告。

Invasive mucormycosis and aspergillosis in a healthy 22-year-old battle casualty: case report.

机构信息

Department of Surgery, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD 20889-5600, USA.

出版信息

Surg Infect (Larchmt). 2011 Oct;12(5):397-400. doi: 10.1089/sur.2010.065. Epub 2011 Oct 17.

DOI:10.1089/sur.2010.065

PMID:22004440

Abstract

BACKGROUND

Invasive mucormycosis or aspergillosis is a life-threatening infection. The disease typically occurs in immunocompromised patients (e.g., those with diabetes mellitus or burns) but is rarely serious in otherwise-healthy young trauma patients.

METHODS

Case report and literature review.

RESULTS

A previously-healthy 22-year-old United States Marine who sustained large soft tissue injuries in support of Operation Enduring Freedom underwent multiple operations in theater to stabilize his wounds. He was evacuated first to Landstuhl Regional Medical Center in Germany and thence to the National Naval Medical Center in Maryland, where appropriate antifungal therapies were initiated and wide débridements were undertaken without success. His clinical status deteriorated, and he died. Tissue examination revealed systemic invasive mucormycosis and aspergillosis.

CONCLUSION

The suspicion of invasive fungal infections must be tested early if intervention is to be curative.

摘要

背景

侵袭性毛霉病或曲霉菌病是一种危及生命的感染。这种疾病通常发生在免疫功能低下的患者（如糖尿病或烧伤患者）中，但在其他健康的年轻创伤患者中很少见。

方法

病例报告和文献复习。

结果

一位之前健康的 22 岁美国海军陆战队员，在支持“持久自由行动”中遭受了大面积软组织损伤，在战区接受了多次手术以稳定伤口。他首先被疏散到德国兰施图尔地区医疗中心，然后被转移到马里兰州的国家海军医疗中心，在那里开始了适当的抗真菌治疗，并进行了广泛的清创术，但没有成功。他的临床状况恶化，最终死亡。组织检查显示全身性侵袭性毛霉病和曲霉菌病。