National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5a, Copenhagen, Denmark.
Scand J Public Health. 2011 Dec;39(8):880-7. doi: 10.1177/1403494811425605. Epub 2011 Oct 19.
Light-to-moderate alcohol drinking is associated with a decreased risk of ischaemic heart disease (IHD). However, drinking heavily and in binges has been suggested to increase IHD risk. This complexity makes the issue of binge drinking within the light-to-moderate alcohol range an important area for further investigation.
This population-based cohort study included 26,786 men and women who participated in the Danish National Cohort Study in 1994, 2000, and 2005. Binge drinking (defined >5 drinks/day) and risk of IHD and all-cause mortality was investigated among light-to-moderate drinkers (defined ≤21 and ≤14 drinks/week for men and women, respectively). In the entire study population, we investigated the association between drinking frequency, separately and combined with total weekly alcohol intake, and risk of IHD and all-cause mortality.
1136 individuals developed IHD during a mean follow up of 6.9 years. Among male light-to-moderate drinkers reporting occasional binge drinking, the hazard ratio (HR) of IHD was 0.81 (95% CI 0.61-1.08) compared to male light-to-moderate drinkers reporting no binge drinking. Corresponding HR for women was 0.97 (95% CI 0.54-1.76). For women drinking 5-6 days/week, the risk of IHD was lower than for women drinking 1-2 days/week (HR 0.54, 95% CI 0.32-0.90). We did not observe any patterns when looking at combinations of total weekly alcohol intake and drinking frequency.
Among light-to-moderate alcohol drinkers, binge drinking was not associated with risk of IHD and all-cause mortality. Overall, drinking frequency did not appear to be an important determinant of the risk of IHD and all-cause mortality.
轻度至中度饮酒与缺血性心脏病（IHD）风险降低有关。然而，大量饮酒和狂饮已被认为会增加 IHD 风险。这种复杂性使得轻至中度饮酒范围内的狂饮问题成为进一步研究的重要领域。
这项基于人群的队列研究纳入了 1994 年、2000 年和 2005 年参加丹麦全国队列研究的 26786 名男性和女性。在轻至中度饮酒者（男性和女性分别定义为≤21 份和≤14 份/周）中，研究了狂饮（定义为>5 份/天）与 IHD 和全因死亡率之间的关系。在整个研究人群中，我们研究了饮酒频率与总每周酒精摄入量分别和联合与 IHD 和全因死亡率之间的关系。
在平均 6.9 年的随访期间，有 1136 人发生了 IHD。在报告偶尔狂饮的男性轻至中度饮酒者中，IHD 的危险比（HR）为 0.81（95%CI 0.61-1.08），而不报告狂饮的男性轻至中度饮酒者为 0.81（95%CI 0.61-1.08）。女性对应的 HR 为 0.97（95%CI 0.54-1.76）。每周饮酒 5-6 天的女性患 IHD 的风险低于每周饮酒 1-2 天的女性（HR 0.54，95%CI 0.32-0.90）。当观察总每周酒精摄入量和饮酒频率的组合时，我们没有观察到任何模式。
在轻至中度饮酒者中，狂饮与 IHD 和全因死亡率无关。总体而言，饮酒频率似乎不是 IHD 和全因死亡率风险的重要决定因素。
