Pedersen Jane Østergaard, Heitmann Berit Lilienthal, Schnohr Peter, Grønbaek Morten
National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 2nd Floor, 1399 Copenhagen, Denmark.
Eur Heart J. 2008 Jan;29(2):204-12. doi: 10.1093/eurheartj/ehm574. Epub 2008 Jan 9.
To determine the combined influence of leisure-time physical activity and weekly alcohol intake on the risk of subsequent fatal ischaemic heart disease (IHD) and all-cause mortality.
Prospective cohort study of 11 914 Danes aged 20 years or older and without pre-existing IHD. During approximately 20 years of follow-up, 1242 cases of fatal IHD occurred and 5901 died from all causes. Within both genders, being physically active was associated with lower hazard ratios (HR) of both fatal IHD and all-cause mortality than being physically inactive. Further, weekly alcohol intake was inversely associated with fatal IHD and had a U-shaped association with all-cause mortality. Within level of physical activity, non-drinkers had the highest HR of fatal IHD, whereas both non-drinkers and heavy drinkers had the highest HR of all-cause mortality. Further, the physically inactive had the highest HR of both fatal IHD and all-cause mortality within each category of weekly alcohol intake. Thus, the HR of both fatal IHD and all-cause mortality were low among the physically active who had a moderate alcohol intake. Conclusion Leisure-time physical activity and a moderate weekly alcohol intake are both important to lower the risk of fatal IHD and all-cause mortality.
确定休闲时间体育活动和每周酒精摄入量对后续致命性缺血性心脏病（IHD）风险和全因死亡率的综合影响。
对11914名20岁及以上且无既往IHD的丹麦人进行前瞻性队列研究。在大约20年的随访期间，发生了1242例致命性IHD病例，5901人死于各种原因。在两性中，与不进行体育活动的人相比，进行体育活动与致命性IHD和全因死亡率的较低风险比（HR）相关。此外，每周酒精摄入量与致命性IHD呈负相关，与全因死亡率呈U形关联。在体育活动水平内，不饮酒者的致命性IHD风险比最高，而不饮酒者和大量饮酒者的全因死亡率风险比最高。此外，在每周酒精摄入量的每个类别中，不进行体育活动者的致命性IHD和全因死亡率风险比最高。因此，在进行体育活动且每周适度饮酒的人群中，致命性IHD和全因死亡率的风险比均较低。结论休闲时间体育活动和每周适度饮酒对于降低致命性IHD风险和全因死亡率均很重要。
