Am J Epidemiol. 2021 Aug 1;190(8):1592-1603. doi: 10.1093/aje/kwab063.
Norwegian health survey data (1987-2003) were analyzed to determine if binge drinking increases the risk of incident major events from ischemic heart disease (IHD) and stroke. Among current drinkers reporting average alcohol intakes of 2.00-59.99 g/day (n = 44,476), frequent binge drinking (≥5 units at least once per month) was not associated with a greater risk of IHD (adjusted hazard ratio (HR) = 0.91, 95% confidence interval (CI): 0.76, 1.09) or stroke (adjusted HR = 0.98, 95% CI: 0.81, 1.19), in comparison with participants who reported that they never or only infrequently (less than once per month) had episodes of binge drinking. Participants with an average alcohol intake of 2.00-59.99 g/day had a lower risk of IHD in comparison with participants with very low intakes (<2.00 g/day), both among frequent binge drinkers (adjusted HR = 0.67, 95% CI: 0.56, 0.80) and among never/infrequent binge drinkers (adjusted HR = 0.75, 95% CI: 0.67, 0.84). The findings suggest that frequent binge drinking, independent of average alcohol intake, does not increase the risk of incident IHD or stroke events. However, the findings should be interpreted in light of the limitations of the study design.
对挪威健康调查数据(1987-2003 年)进行分析,以确定 binge drinking 是否会增加缺血性心脏病(IHD)和中风的发病风险。在报告平均酒精摄入量为 2.00-59.99 g/天的当前饮酒者中(n=44476),频繁 binge drinking(每月至少一次饮酒 5 个单位以上)与 IHD(调整后的危险比(HR)=0.91,95%置信区间(CI):0.76,1.09)或中风(调整后的 HR=0.98,95%CI:0.81,1.19)的发病风险增加无关,与报告从不或很少(每月少于一次) binge drinking 的参与者相比。与低摄入量(<2.00 g/天)的参与者相比,每日酒精摄入量为 2.00-59.99 g 的参与者的 IHD 发病风险较低,在频繁 binge drinkers(调整后的 HR=0.67,95%CI:0.56,0.80)和从不/很少 binge drinkers(调整后的 HR=0.75,95%CI:0.67,0.84)中均如此。这些发现表明,频繁 binge drinking 独立于平均酒精摄入量,不会增加 IHD 或中风事件的发病风险。然而,应该根据研究设计的局限性来解释这些发现。