小鼠巨噬细胞炎性蛋白2及其人类同源物的cDNA克隆与特性分析
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.
作者信息
Tekamp-Olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, van Deventer S, Cerami A
机构信息
Chiron Corporation, Emeryville, California 94608.
出版信息
J Exp Med. 1990 Sep 1;172(3):911-9. doi: 10.1084/jem.172.3.911.
Abstract
A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2 from a library prepared from phorbol myristate acetate-treated and LPS-stimulated U937 cells. Two homologues were isolated and sequenced. Human MIP-2 alpha and MIP-2 beta are highly homologous to each other and to a previously isolated gene, human gro/melanoma growth-stimulating activity (MGSA). These three human genes, MIP-2 alpha, MIP-2 beta, and gro/MGSA, constitute a sub-family within the cytokine family represented by platelet factor 4 and interleukin 8.
摘要
从小鼠巨噬细胞炎性蛋白2（MIP - 2）的cDNA克隆已从用脂多糖（LPS）刺激的RAW 264.7细胞构建的文库中分离出来，并测定了核苷酸序列。该cDNA用于从佛波酯肉豆蔻酸酯乙酸盐处理且LPS刺激的U937细胞构建的文库中克隆MIP - 2人类同源物的cDNA。分离并测序了两个同源物。人类MIP - 2α和MIP - 2β彼此高度同源，并且与先前分离的基因人类生长调节致癌基因/黑素瘤生长刺激活性（MGSA）高度同源。这三个人类基因，MIP - 2α、MIP - 2β和生长调节致癌基因/MGSA，在以血小板因子4和白细胞介素8为代表的细胞因子家族中构成一个亚家族。
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本文引用的文献
1
Molecular cloning of gene sequences regulated by platelet-derived growth factor.血小板衍生生长因子调控的基因序列的分子克隆
Cell. 1983 Jul;33(3):939-47. doi: 10.1016/0092-8674(83)90037-5.
2
How signal sequences maintain cleavage specificity.信号序列如何维持切割特异性。
J Mol Biol. 1984 Feb 25;173(2):243-51. doi: 10.1016/0022-2836(84)90192-x.
3
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides.真核生物和原核生物信号肽中一个假定的信号肽酶识别位点及序列。
J Mol Biol. 1983 Jun 25;167(2):391-409. doi: 10.1016/s0022-2836(83)80341-6.
4
A method for isolation of intact, translationally active ribonucleic acid.一种分离完整的、具有翻译活性的核糖核酸的方法。
DNA. 1983;2(4):329-35. doi: 10.1089/dna.1983.2.329.
5
A general method applicable to the search for similarities in the amino acid sequence of two proteins.一种适用于寻找两种蛋白质氨基酸序列相似性的通用方法。
J Mol Biol. 1970 Mar;48(3):443-53. doi: 10.1016/0022-2836(70)90057-4.
6
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.点突变确定了AUG起始密码子侧翼的一个序列，该序列可调节真核生物核糖体的翻译。
Cell. 1986 Jan 31;44(2):283-92. doi: 10.1016/0092-8674(86)90762-2.
7
Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.γ干扰素通过转录调控一个与血小板蛋白具有同源性的早期反应基因。
Nature. 1985;315(6021):672-6. doi: 10.1038/315672a0.
8
Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries.在氯化铵中与碱基组成无关的杂交：一种用于高度复杂基因文库寡核苷酸筛选的方法。
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1585-8. doi: 10.1073/pnas.82.6.1585.
9
Structure of the rat platelet factor 4 gene: a marker for megakaryocyte differentiation.大鼠血小板因子4基因的结构：巨核细胞分化的一个标志物。
Mol Cell Biol. 1987 Feb;7(2):898-904. doi: 10.1128/mcb.7.2.898-904.1987.
10
Isolation and amino acid sequence of bovine platelet factor 4.牛血小板因子4的分离及氨基酸序列
Arch Biochem Biophys. 1986 Oct;250(1):249-56. doi: 10.1016/0003-9861(86)90723-x.
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