Smith J B, Bocchieri M H, Smith J B, Sherbin-Allen L, Abruzzo J L
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Rheumatol Int. 1990;10(3):131-4. doi: 10.1007/BF02274828.
Synovial fluids (SF) from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) and various other arthritides were examined for the presence of colony stimulating factors (CSF). CSF was found in 7 of 13 (54%) SF from OA patients and in 8 of 12 (67%) SF from RA patients. It was also found in SF from patients with other arthropathies including 5 of 5 samples from patients with septic arthritis. Inhibition studies employing monospecific antisera indicated that in both RA and OA, CSF was of the macrophage type (M-CSF). While CSF was found in both inflammatory and noninflammatory effusions, significantly greater numbers of colonies were stimulated by RA SF than by OA SF and in general greater numbers of colonies correlated with higher SF leukocyte counts. Our data suggest that CSF as well as other cytokines may be involved in the perpetuation of joint destruction that occurs in various rheumatological conditions.
对骨关节炎（OA）、类风湿关节炎（RA）及其他各种关节炎患者的滑液（SF）进行了集落刺激因子（CSF）检测。在13例OA患者的滑液中有7例（54%）检测到CSF，在12例RA患者的滑液中有8例（67%）检测到CSF。在包括5例脓毒性关节炎患者样本中的5例在内的其他关节病患者的滑液中也检测到了CSF。采用单特异性抗血清的抑制研究表明，在RA和OA中，CSF均为巨噬细胞型（M-CSF）。虽然在炎性和非炎性积液中均检测到CSF，但RA滑液刺激产生的集落数量明显多于OA滑液，总体而言，集落数量越多与滑液白细胞计数越高相关。我们的数据表明，CSF以及其他细胞因子可能参与了各种风湿性疾病中发生的关节破坏的持续过程。
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