• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Supramolecular hydrogelators of N-terminated dipeptides selectively inhibit cancer cells.N 端二肽的超分子水凝胶因子选择性地抑制癌细胞。
Chem Commun (Camb). 2011 Dec 21;47(47):12625-7. doi: 10.1039/c1cc15577f. Epub 2011 Oct 31.
2
12-Hydroxy-Lauric Acid Tethered Self-Assembled Heterochiral Diphenylalanine-Based Mechanoresponsive and Proteolytically Stable Hydrogel: A Dual Player for Handling Cancer and Bacterial Challenges.
ACS Appl Bio Mater. 2025 Feb 17;8(2):1108-1125. doi: 10.1021/acsabm.4c01438. Epub 2025 Jan 21.
3
Salt-induced hydrogelation of functionalised-dipeptides at high pH.高 pH 值下功能化二肽的盐诱导水凝胶化。
Chem Commun (Camb). 2011 Nov 28;47(44):12071-3. doi: 10.1039/c1cc15474e. Epub 2011 Oct 17.
4
Stimuli-Responsive Dipeptide-Protein Hydrogels through Schiff Base Coassembly.通过席夫碱共组装制备刺激响应二肽-蛋白质水凝胶。
Macromol Rapid Commun. 2017 Oct;38(20). doi: 10.1002/marc.201700408. Epub 2017 Aug 25.
5
Ferrocenoyl phenylalanine: a new strategy toward supramolecular hydrogels with multistimuli responsive properties.二茂铁酰基苯丙氨酸:一种具有多重刺激响应特性的超分子水凝胶的新策略。
J Am Chem Soc. 2013 Sep 11;135(36):13379-86. doi: 10.1021/ja403345p. Epub 2013 Aug 28.
6
Release behavior of salicylic acid in supramolecular hydrogels formed by l-phenylalanine derivatives as hydrogelator.由L-苯丙氨酸衍生物作为水凝胶剂形成的超分子水凝胶中水杨酸的释放行为。
Int J Pharm. 2008 Jun 5;357(1-2):95-9. doi: 10.1016/j.ijpharm.2008.01.054. Epub 2008 Feb 6.
7
Controlling self-assembly of diphenylalanine peptides at high pH using heterocyclic capping groups.使用杂环封端基团在高 pH 值下控制二苯丙氨酸肽的自组装。
Sci Rep. 2017 Mar 8;7:43947. doi: 10.1038/srep43947.
8
Construction of self-assembled nanostructure-based tetraphenylethylene dipeptides: supramolecular nanobelts as biomimetic hydrogels for cell adhesion and proliferation.基于自组装纳米结构的四苯基乙烯二肽的构建:作为用于细胞黏附和增殖的仿生水凝胶的超分子纳米带
J Mater Chem B. 2020 Aug 26;8(33):7483-7493. doi: 10.1039/d0tb01147a.
9
Probing gelation ability for a library of dipeptide gelators.探究二肽凝胶剂文库的凝胶化能力。
J Colloid Interface Sci. 2015 Oct 1;455:24-31. doi: 10.1016/j.jcis.2015.05.032. Epub 2015 May 23.
10
Phenylalanine-containing cyclic dipeptides--the lowest molecular weight hydrogelators based on unmodified proteinogenic amino acids.含苯丙氨酸的环二肽——基于未修饰的天然氨基酸的最低分子量水凝胶因子。
Chem Commun (Camb). 2013 Sep 14;49(71):7818-20. doi: 10.1039/c3cc44110e.

引用本文的文献

1
Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups.具有大体积芳基端基的肽缀合物的自组装、生物活性和纳米材料应用。
ACS Appl Bio Mater. 2023 Feb 20;6(2):384-409. doi: 10.1021/acsabm.2c01041. Epub 2023 Feb 3.
2
Biological functions of supramolecular assemblies of small molecules in cellular environment.小分子超分子聚集体在细胞环境中的生物学功能。
RSC Chem Biol. 2021 Apr 1;2(2):289-305. doi: 10.1039/d0cb00219d. Epub 2021 Jan 28.
3
Self-Assembly Mechanism of a Peptide-Based Drug Delivery Vehicle.基于肽的药物递送载体的自组装机制
ACS Omega. 2018 Mar 31;3(3):3143-3155. doi: 10.1021/acsomega.7b01871. Epub 2018 Mar 15.
4
Supramolecular biofunctional materials.超分子生物功能材料
Biomaterials. 2017 Jun;129:1-27. doi: 10.1016/j.biomaterials.2017.03.014. Epub 2017 Mar 12.
5
Gd(III)-induced Supramolecular Hydrogelation with Enhanced Magnetic Resonance Performance for Enzyme Detection.基于 Gd(III)的超分子水凝胶用于增强磁共振性能的酶检测。
Sci Rep. 2017 Jan 11;7:40172. doi: 10.1038/srep40172.
6
Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules.配体-受体相互作用调节小分子酶指导的自组装的能量景观。
J Am Chem Soc. 2016 Nov 30;138(47):15397-15404. doi: 10.1021/jacs.6b07677. Epub 2016 Nov 15.
7
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.超分子水凝胶剂与水凝胶:从软物质到分子生物材料
Chem Rev. 2015 Dec 23;115(24):13165-307. doi: 10.1021/acs.chemrev.5b00299. Epub 2015 Dec 8.
8
Glutathione-triggered formation of a Fmoc-protected short peptide-based supramolecular hydrogel.谷胱甘肽引发的基于Fmoc保护的短肽的超分子水凝胶的形成。
PLoS One. 2014 Sep 15;9(9):e106968. doi: 10.1371/journal.pone.0106968. eCollection 2014.
9
Self-Assembly for the Synthesis of Functional Biomaterials.用于合成功能性生物材料的自组装
Acta Mater. 2013 Feb 1;61(3):912-930. doi: 10.1016/j.actamat.2012.10.046.

本文引用的文献

1
Separation of proteins using supramolecular gel electrophoresis.使用超分子凝胶电泳分离蛋白质。
Chem Commun (Camb). 2011 Oct 7;47(37):10344-6. doi: 10.1039/c1cc13826j. Epub 2011 Aug 19.
2
What kind of "soft materials" can we design from molecular gels?我们可以从分子凝胶设计出什么样的“软材料”?
Chem Asian J. 2011 Feb 1;6(2):266-82. doi: 10.1002/asia.201000217. Epub 2010 Aug 16.
3
Versatile small-molecule motifs for self-assembly in water and the formation of biofunctional supramolecular hydrogels.多功能小分子基元在水中的自组装及生物功能超分子水凝胶的形成。
Langmuir. 2011 Jan 18;27(2):529-37. doi: 10.1021/la1020324. Epub 2010 Jul 7.
4
Self-assembly of peptide amphiphiles: from molecules to nanostructures to biomaterials.肽两亲体的自组装:从分子到纳米结构到生物材料。
Biopolymers. 2010;94(1):1-18. doi: 10.1002/bip.21328.
5
Salt, pH and thermoresponsive supramolecular hydrogel of N-(4-n-tetradecyloxybenzoyl)-L-carnosine.N-(4-正十四烷氧基苯甲酰基)-L-肉碱的盐、pH 值和温度响应超分子水凝胶。
Chem Commun (Camb). 2009 Dec 7(45):6997-9. doi: 10.1039/b914665b. Epub 2009 Oct 6.
6
Tunable mechanics of peptide nanofiber gels.肽纳米纤维凝胶的可调力学性能。
Langmuir. 2010 Mar 2;26(5):3641-7. doi: 10.1021/la9030969.
7
Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative.酶促分子自组装赋予紫杉醇衍生物纳米纤维和超分子水凝胶。
J Am Chem Soc. 2009 Sep 30;131(38):13576-7. doi: 10.1021/ja904411z.
8
Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells.基于自组装肽的水凝胶作为贴壁依赖性细胞的支架。
Biomaterials. 2009 May;30(13):2523-30. doi: 10.1016/j.biomaterials.2009.01.010. Epub 2009 Feb 7.
9
Designing peptide based nanomaterials.设计基于肽的纳米材料。
Chem Soc Rev. 2008 Apr;37(4):664-75. doi: 10.1039/b609047h. Epub 2008 Jan 10.
10
Transition of cationic dipeptide nanotubes into vesicles and oligonucleotide delivery.阳离子二肽纳米管向囊泡的转变及寡核苷酸递送
Angew Chem Int Ed Engl. 2007;46(14):2431-4. doi: 10.1002/anie.200603387.

N 端二肽的超分子水凝胶因子选择性地抑制癌细胞。

Supramolecular hydrogelators of N-terminated dipeptides selectively inhibit cancer cells.

机构信息

Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA.

出版信息

Chem Commun (Camb). 2011 Dec 21;47(47):12625-7. doi: 10.1039/c1cc15577f. Epub 2011 Oct 31.

DOI:10.1039/c1cc15577f
PMID:22037699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3235792/
Abstract

Consisting of N-terminated diphenylalanine, a new type of supramolecular hydrogelators forms hydrogels within a narrow pH window (pH 5.0 to 6.0) and selectively inhibits growth of HeLa cells, which provides important and useful insights for designing molecular nanofibers as potential nanomedicines.

摘要

由 N 端二苯丙氨酸组成的新型超分子水凝胶形成剂在较窄的 pH 窗口(pH5.0 至 6.0)内形成水凝胶,并选择性地抑制 HeLa 细胞的生长,这为设计作为潜在纳米药物的分子纳米纤维提供了重要而有用的见解。