过氧乙酸亚急性暴露对Wistar大鼠脂质过氧化和肝酶的影响。
The effects of subacute exposure of peracetic Acid on lipid peroxidation and hepatic enzymes in wistar rats.
作者信息
Marjani Abdoljalal, Golalipour Mohammad J, Gharravi Anneh M
出版信息
Oman Med J. 2010 Oct;25(4):256-60. doi: 10.5001/omj.2010.77.
OBJECTIVES
This study was undertaken to determine the effect of subacute exposure of peracetic acid on lipid peroxidation and hepatic enzymes in Wistar rats.
METHODS
48 male animals in Treatment Group I, II and III received 0.2%, 2% and 20% peracetic acid daily for 2 and 4 weeks.
RESULTS
Serum malondialdehyde increased and Alanine Transaminase and Aspartate Transaminase decreased significantly in groups 2 and 3, compared to the control group. The malondialdehyde, Alanine Transaminase and Aspartate Transaminase with 0.2% and 2% doses of peracetic acid for 2 weeks do not lead to the alteration of malondialdehyde and enzyme activities.
CONCLUSION
This study demonstrated that the enhancement of malondialdehyde could provide an oxidative damage induced by disinfectant peroxidation at 20% and 2% doses at 2 and 4 weeks. The consumption of peroxidation with 20% for 2 weeks and 2% for 4 weeks can cause the increase of malondialdehyde and the decrease of enzyme activities, respectively.
目的
本研究旨在确定过氧乙酸亚急性暴露对Wistar大鼠脂质过氧化和肝酶的影响。
方法
治疗组I、II和III中的48只雄性动物分别连续2周和4周每日接受0.2%、2%和20%的过氧乙酸。
结果
与对照组相比，第2组和第3组血清丙二醛升高，谷丙转氨酶和谷草转氨酶显著降低。0.2%和2%剂量的过氧乙酸连续2周处理，丙二醛、谷丙转氨酶和谷草转氨酶未导致丙二醛和酶活性改变。
结论
本研究表明，2周和4周时，20%和2%剂量的消毒剂过氧化可诱导氧化损伤，导致丙二醛升高。20%剂量连续2周和2%剂量连续4周的过氧化消耗分别可导致丙二醛增加和酶活性降低。
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