Laboratory of Neurophysiology, School of Medicine, Université Libre de Bruxelles, ULB, Brussels, Belgium.
EMBO J. 2012 Feb 1;31(3):640-53. doi: 10.1038/emboj.2011.400. Epub 2011 Nov 8.
The dorsal striatum is critically involved in a variety of motor behaviours, including regulation of motor activity, motor skill learning and motor response to psychostimulant and neuroleptic drugs, but contribution of D(2)R-striatopallidal and D(1)R-striatonigral neurons in the dorsomedial (DMS, associative) and dorsolateral (DLS, sensorimotor) striatum to distinct functions remains elusive. To delineate cell type-specific motor functions of the DMS or the DLS, we selectively ablated D(2)R- and D(1)R-expressing striatal neurons with spatial resolution. We found that associative striatum exerts a population-selective control over locomotion and reactivity to novelty, striatopallidal and striatonigral neurons inhibiting and stimulating exploration, respectively. Further, DMS-striatopallidal neurons are involved only in early motor learning whereas gradual motor skill acquisition depends on striatonigral neurons in the sensorimotor striatum. Finally, associative striatum D(2)R neurons are required for the cataleptic effect of the typical neuroleptic drug haloperidol and for amphetamine motor response sensitization. Altogether, these data provide direct experimental evidence for cell-specific topographic functional organization of the dorsal striatum.
背侧纹状体在多种运动行为中起着至关重要的作用，包括调节运动活动、运动技能学习以及对精神兴奋剂和神经安定药的运动反应，但背侧纹状体中 D2R-纹状体苍白球和 D1R-纹状体黑质神经元对不同功能的贡献仍不清楚。为了描绘 DMS（关联）和 DLS（感觉运动）纹状体中特定于细胞类型的运动功能，我们以空间分辨率选择性地消融了表达 D2R 和 D1R 的纹状体神经元。我们发现，关联纹状体对运动和对新奇事物的反应具有群体选择性控制，纹状体苍白球和纹状体黑质神经元分别抑制和刺激探索。此外，DMS-纹状体苍白球神经元仅参与早期运动学习，而逐渐的运动技能习得取决于感觉运动纹状体中的纹状体黑质神经元。最后，关联纹状体 D2R 神经元是典型神经安定药氟哌啶醇的镇静作用和安非他命运动反应敏感化所必需的。总之，这些数据为背侧纹状体的特定细胞拓扑功能组织提供了直接的实验证据。
