关于赭曲霉毒素 A 对雏鸡致癌和毒性作用的研究。
Studies on carcinogenic and toxic effects of ochratoxin A in chicks.
机构信息
Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria.
出版信息
Toxins (Basel). 2010 Apr;2(4):649-64. doi: 10.3390/toxins2040649. Epub 2010 Apr 12.
Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.
研究了赭曲霉毒素 A（OTA）在各种内脏器官中的致癌/毒性作用。与仅给予 5 ppm OTA 的雏鸡相比，给予 25 ppm L-β-苯丙氨酸（PHE）外加 5 ppm OTA 的雏鸡中 OTA 诱导的肿瘤数量相似，这表明 PHE 不能用作真正的保护剂，不能抵抗 OTA 对雏鸡的致癌或毒性作用。OTA 被发现会引起肝脏和肾脏的强烈退行性变化、淋巴器官的退行性变化和细胞耗竭、大脑的水肿和退行性变化、肌肉出血和骨髓脂肪变化。发现 OTA 在雏鸡中的致癌作用的靶器官是肾脏和肝脏。
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