Ventura Marco, Turroni Francesca, van Sinderen Douwe
Laboratory of Probiogenomics, Department of Genetics, Biology of Microorganisms, Anthropology and Evolution, University of Parma, Parma, Italy.
Bioeng Bugs. 2012 Mar-Apr;3(2):73-9. doi: 10.4161/bbug.18540. Epub 2012 Mar 1.
Bifidobacteria and lactobacilli are widely exploited as health-promoting bacteria in many functional foods. However, the molecular mechanisms as to how these bacteria positively impact on host health are far from completely understood. For this reason these microorganisms represent a growing area of interest with respect to their genomics, molecular biology and genetics. Recent genome sequencing of a large number of strains of bifidobacteria and lactobacilli has allowed access to the complete genetic makeup of representative members of these bacteria. Here, we will discuss how the analysis of genomic data has helped us to understand the mechanisms by which these bacteria adapt to the specific environment of the gastrointestinal tract, while also revealing genetic functions that mediate specific host-microbe interactions.
双歧杆菌和乳酸杆菌作为促进健康的细菌在许多功能性食品中得到广泛应用。然而，关于这些细菌如何对宿主健康产生积极影响的分子机制尚未完全了解。因此，就其基因组学、分子生物学和遗传学而言，这些微生物代表了一个日益受到关注的领域。最近对大量双歧杆菌和乳酸杆菌菌株进行的基因组测序，使我们能够了解这些细菌代表性成员的完整基因组成。在这里，我们将讨论基因组数据分析如何帮助我们理解这些细菌适应胃肠道特定环境的机制，同时揭示介导特定宿主-微生物相互作用的基因功能。
