Gastrointestinal Endoscopy Unit, University of São Paulo, São Paulo, Brazil.
World J Gastroenterol. 2011 Oct 21;17(39):4408-13. doi: 10.3748/wjg.v17.i39.4408.
To compare narrow-band imaging (NBI) without image magnification, and chromoendoscopy with Lugol's solution for detecting high-grade dysplasia and intramucosal esophageal squamous cell carcinoma (SCC) in patients with head and neck cancer.
This was a prospective observational study of 129 patients with primary head and neck tumors consecutively referred to the Gastrointestinal Endoscopy Unit of Hospital das Clínicas, São Paulo University Medical School, Brazil, between August 2006 and February 2007. Conventional examinations with NBI and Lugol chromoendoscopy were consecutively performed, and the discovered lesions were mapped, recorded and sent for biopsy. The results of the three methods were compared regarding sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood value and negative likelihood value.
Of the 129 patients, nine (7%) were diagnosed with SCC, 5 of which were in situ and 4 which were intramucosal. All carcinomas were detected through NBI and Lugol chromoendoscopy. Only 4 lesions were diagnosed through conventional examination, all of which were larger than 10 mm.
NBI technology with optical filters has high sensitivity and high negative predictive value for detecting superficial esophageal SCC, and produces results comparable to those obtained with 2.5% Lugol chromoendoscopy.
比较不放大图像的窄带成像（NBI）与卢戈氏液染色内镜在检测头颈部癌症患者中高级别上皮内瘤变和黏膜内食管鳞状细胞癌（SCC）中的作用。
这是一项前瞻性观察研究，纳入了 2006 年 8 月至 2007 年 2 月间巴西圣保罗大学医学院附属医院胃肠内镜科连续就诊的 129 例头颈部原发性肿瘤患者。连续进行常规 NBI 检查和卢戈氏液染色内镜检查，并对发现的病变进行定位、记录和活检。比较三种方法的灵敏度、特异性、准确性、阳性预测值、阴性预测值、阳性似然比和阴性似然比。
129 例患者中，9 例（7%）被诊断为 SCC，其中 5 例为原位癌，4 例为黏膜内癌。所有的癌均通过 NBI 和卢戈氏液染色内镜发现。仅通过常规检查诊断出 4 处病变，均大于 10mm。
NBI 技术结合光学滤光片对检测浅表性食管 SCC 具有较高的灵敏度和阴性预测值，其结果与 2.5%卢戈氏液染色内镜相当。
