测量中国大陆癌症儿童的健康相关生活质量：PedsQL 4.0 通用核心量表和 3.0 癌症模块中文版的可行性、信度和效度。
Measuring health-related quality of life in children with cancer living in Mainland China: feasibility, reliability and validity of the Chinese Mandarin version of PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module.
机构信息
Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai 201102, China.
出版信息
Health Qual Life Outcomes. 2011 Nov 23;9:103. doi: 10.1186/1477-7525-9-103.
BACKGROUND
The Pediatric Quality of Life Inventory (PedsQL) is widely used instrument to measure pediatric health-related quality of life (HRQOL) for children aged 2 to 18 years. The purpose of the current study was to investigate the feasibility, reliability and validity of the Chinese mandarin version of the PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module in a group of Chinese children with cancer.
METHODS
The PedsQL 4.0 Genetic Core Scales and the PedsQL 3.0 Cancer Module were administered to children with cancer (aged 5-18 years) and parents of such children (aged 2-18 years). For comparison, a survey on a demographically group-matched sample of the general population with children (aged 5-18) and parents of children (aged 2-18 years) was conducted with the PedsQL 4.0 Genetic Core Scales.
RESULT
The minimal mean percentage of missing item responses (except the School Functioning scale) supported the feasibility of the PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module for Chinese children with cancer. Most of the scales showed satisfactory reliability with Cronbach's α of exceeding 0.70, and all scales demonstrated sufficient test-retest reliability. Assessing the clinical validity of the questionnaires, statistically significant difference was found between healthy children and children with cancer, and between children on-treatment versus off-treatment ≥12 months. Positive significant correlations were observed between the scores of the PedsQL 4.0 Generic Core Scale and the PedsQL 3.0 Cancer Module. Exploratory factor analysis demonstrated sufficient factorial validity. Moderate to good agreement was found between child self- and parent proxy-reports.
CONCLUSION
The findings support the feasibility, reliability and validity of the Chinese Mandarin version of PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module in children with cancer living in mainland China.
背景
儿科生存质量量表（PedsQL）是一种广泛用于测量 2 至 18 岁儿童健康相关生存质量（HRQOL）的工具。本研究的目的是调查中文版 PedsQL 4.0 通用核心量表和 3.0 癌症模块在一组中国癌症儿童中的可行性、信度和效度。
方法
将 PedsQL 4.0 遗传核心量表和 PedsQL 3.0 癌症模块应用于癌症儿童（5-18 岁）及其父母（2-18 岁）。为了进行比较，还对一组年龄匹配的一般人群中的儿童（5-18 岁）及其父母（2-18 岁）进行了 PedsQL 4.0 通用核心量表调查。
结果
除了学校功能量表外，最小平均缺失项目响应百分比支持了中文版 PedsQL 4.0 通用核心量表和 3.0 癌症模块对中国癌症儿童的可行性。大多数量表的 Cronbach's α 超过 0.70，表明具有良好的信度，所有量表均表现出足够的重测信度。评估问卷的临床有效性时，发现健康儿童与癌症儿童之间、治疗中与治疗后≥12 个月儿童之间存在统计学显著差异。PedsQL 4.0 通用核心量表的评分与 PedsQL 3.0 癌症模块之间存在显著正相关。探索性因子分析表明具有足够的因子有效性。儿童自我报告和父母代理报告之间存在中度至良好的一致性。
结论
研究结果支持中国大陆癌症儿童使用中文版 PedsQL 4.0 通用核心量表和 3.0 癌症模块的可行性、信度和效度。
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