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1
Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase.包含五个钴胺素基因的反硝化假单胞菌5.4千碱基DNA片段的核苷酸序列以及编码S-腺苷-L-甲硫氨酸：尿卟啉原III甲基转移酶和钴胺酸a，c-二酰胺合酶的结构基因的鉴定。
J Bacteriol. 1990 Oct;172(10):5968-79. doi: 10.1128/jb.172.10.5968-5979.1990.
2
Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.对一个8.7千碱基的反硝化假单胞菌片段进行遗传和序列分析，该片段携带8个参与前咕啉-2转化为钴胺酸的基因。
J Bacteriol. 1990 Oct;172(10):5980-90. doi: 10.1128/jb.172.10.5980-5990.1990.
3
Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase.一个包含五个钴胺素（cob）基因的13.1千碱基对反硝化假单胞菌DNA片段的核苷酸序列与遗传分析，以及编码钴胺素（I）腺苷转移酶、钴胺酸合酶和双功能钴胺酰胺激酶-钴胺酰胺磷酸鸟苷基转移酶的结构基因的鉴定。
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5
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J Bacteriol. 1991 Aug;173(15):4893-6. doi: 10.1128/jb.173.15.4893-4896.1991.
6
Structure/function studies on a S-adenosyl-L-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis.对S-腺苷-L-甲硫氨酸依赖性尿卟啉原III C甲基转移酶（SUMT）的结构/功能研究，该酶是四吡咯生物合成的关键调节酶。
J Mol Biol. 2004 Nov 19;344(2):419-33. doi: 10.1016/j.jmb.2004.09.020.
7
Purification and characterization of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Pseudomonas denitrificans.反硝化假单胞菌中S-腺苷-L-甲硫氨酸：尿卟啉原III甲基转移酶的纯化与特性分析
J Bacteriol. 1989 Aug;171(8):4222-31. doi: 10.1128/jb.171.8.4222-4231.1989.
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J Bacteriol. 1991 Oct;173(19):6058-65. doi: 10.1128/jb.173.19.6058-6065.1991.
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Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase.两种反硝化假单胞菌编码烟酸核苷酸：二甲基苯并咪唑磷酸核糖基转移酶和钴胺素（5'-磷酸）合酶的钴胺素基因（cob基因）的遗传分析、核苷酸序列及产物
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Biochem J. 2003 Mar 1;370(Pt 2):505-16. doi: 10.1042/BJ20021443.
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A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis.鼠伤寒沙门氏菌cbiK在钴胺素（维生素B12）和siroheme生物合成中的作用。
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10
Evolutionary recruitment of biochemically specialized subdivisions of Family I within the protein superfamily of aminotransferases.氨基转移酶蛋白质超家族中I类生物化学特化亚群的进化招募。
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包含五个钴胺素基因的反硝化假单胞菌5.4千碱基DNA片段的核苷酸序列以及编码S-腺苷-L-甲硫氨酸：尿卟啉原III甲基转移酶和钴胺酸a，c-二酰胺合酶的结构基因的鉴定。

Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase.

作者信息

Crouzet J, Cauchois L, Blanche F, Debussche L, Thibaut D, Rouyez M C, Rigault S, Mayaux J F, Cameron B

机构信息

Institut des Biotechnologies, Rhône-Poulenc Santé, Centre de Recherche de Vitry, France.

出版信息

J Bacteriol. 1990 Oct;172(10):5968-79. doi: 10.1128/jb.172.10.5968-5979.1990.

DOI:10.1128/jb.172.10.5968-5979.1990
PMID:2211520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC526919/
Abstract

A 5.4-kilobase DNA fragment carrying Pseudomonas denitrificans cob genes has been sequenced. The nucleotide sequence and genetic analysis revealed that this fragment carries five different cob genes (cobA to cobE). Four of these genes present the characteristics of translationally coupled genes. cobA has been identified as the structural gene of S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase (SUMT) because the encoded protein has the same NH2 terminus and molecular weight as those determined for the purified SUMT. For the same reasons the cobB gene was shown to be the structural gene for cobyrinic acid a,c-diamide synthase. Genetic and biochemical data concerning cobC and cobD mutants suggest that the products of these genes are involved in the conversion of cobyric acid to cobinamide.

摘要

一个携带反硝化假单胞菌cob基因的5.4千碱基DNA片段已被测序。核苷酸序列和遗传分析表明，该片段携带五个不同的cob基因（cobA至cobE）。其中四个基因具有翻译偶联基因的特征。cobA已被鉴定为S-腺苷-L-甲硫氨酸：尿卟啉原III甲基转移酶（SUMT）的结构基因，因为编码的蛋白质具有与纯化的SUMT相同的NH2末端和分子量。出于同样的原因，cobB基因被证明是钴胺酸a，c-二酰胺合酶的结构基因。关于cobC和cobD突变体的遗传和生化数据表明，这些基因的产物参与了钴胺酸向辅酶维生素B12的转化。