使用统计标准筛选核酸序列中的潜在同源性。
Use of statistical criteria for screening potential homologies in nucleic acid sequences.
作者信息
Kanehisa M
出版信息
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):203-13. doi: 10.1093/nar/12.1part1.203.
Abstract
We proposed a simple formula to assess the statistical significance of homologous segments found in comparison of two nucleic acid sequences (Goad and Kanehisa, Nucleic Acids Res. 10, 247-263, 1982). This paper clarifies the basic assumptions of the formula and its reliability is examined by Monte Carlo calculations. The results were satisfactory for random sequences. The formula is a useful measure for screening potentially interesting homologies and it can be implemented in any search algorithms. Examples are given for the screening procedure in the graphic display version of the Goad-Kanehisa algorithm.
摘要
我们提出了一个简单的公式，用于评估在比较两个核酸序列时发现的同源片段的统计学显著性（戈德和金久保，《核酸研究》10，247 - 263，1982年）。本文阐明了该公式的基本假设，并通过蒙特卡罗计算检验了其可靠性。对于随机序列，结果令人满意。该公式是筛选潜在有趣同源性的有用方法，可在任何搜索算法中实现。文中给出了戈德 - 金久保算法图形显示版本中筛选程序的示例。
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