Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan.
Gastrointest Endosc. 2012 Mar;75(3):506-12. doi: 10.1016/j.gie.2011.08.020. Epub 2011 Nov 23.
It is commonly recommended that patients refrain from driving for 24 hours after endoscopy for which sedation is given.
The aim of this study was to evaluate psychomotor recovery and blood propofol concentrations after colonoscopy with propofol sedation to determine whether driving might be safe.
A prospective, consecutive study.
Municipal hospital outpatients.
This study involved 48 consecutive patients scheduled for colonoscopy with propofol sedation.
Patient clinical features, psychomotor recovery, and blood concentrations of propofol were assessed. Psychomotor recovery was assessed before colonoscopy and 1 and 2 hours after colonoscopy by using the number connection test and a driving simulator test.
Clinical features, psychomotor recovery, and blood concentration of propofol.
All patients successfully completed the post-sedation assessments. Although there was a significant difference in results of the number connection test between before colonoscopy and 1 hour after colonoscopy, all number connection test results were within normal limits (<40 seconds). Scores were as follows: mean time (standard deviation) before colonoscopy, 32.2 (2.0) seconds (range 29-36 seconds) versus after colonoscopy, 32.7 (2.0) seconds (range 27-38 seconds); P = .0019. Driving skills had recovered to the baseline levels 1 hour after colonoscopy. Scores were as follows: tracking error (%) before colonoscopy, 45.0 (5.6) versus after colonoscopy, 46.0 (5.5); P = .61; accelerating reaction time in seconds before colonoscopy, 0.65 (0.15) versus after colonoscopy, 0.62 (0.14); P = .40; braking reaction time in seconds before colonoscopy, 0.58 (0.13) versus after colonoscopy, 0.61 (0.13); P = .50.
Small sample size, single-center study.
Although consistent findings on the number connection test and driving simulation (psychomotor recovery) test are present as early as 1 hour after propofol sedation, a study of additional numbers of patients as well as different patient populations are needed before these results can be universally recommended.
通常建议接受镇静内镜检查的患者在检查后 24 小时内避免驾驶。
本研究旨在评估接受异丙酚镇静的结肠镜检查后患者的精神运动恢复情况和血液中异丙酚浓度，以确定是否可以安全驾驶。
前瞻性、连续研究。
市立医院门诊。
本研究纳入了 48 例连续接受异丙酚镇静结肠镜检查的患者。
评估患者的临床特征、精神运动恢复情况以及血液中异丙酚浓度。在结肠镜检查前、结肠镜检查后 1 小时和 2 小时使用数字连接测试和驾驶模拟器测试评估精神运动恢复情况。
临床特征、精神运动恢复和异丙酚的血液浓度。
所有患者均成功完成了镇静后评估。尽管数字连接测试结果在结肠镜检查前和结肠镜检查后 1 小时之间存在显著差异，但所有数字连接测试结果均在正常范围内（<40 秒）。结果如下：结肠镜检查前的平均时间（标准差）为 32.2（2.0）秒（范围 29-36 秒），结肠镜检查后为 32.7（2.0）秒（范围 27-38 秒）；P =.0019。结肠镜检查后 1 小时，驾驶技能已恢复至基线水平。结果如下：跟踪误差（%）在结肠镜检查前为 45.0（5.6），结肠镜检查后为 46.0（5.5）；P =.61；结肠镜检查前加速反应时间（秒）为 0.65（0.15），结肠镜检查后为 0.62（0.14）；P =.40；结肠镜检查前制动反应时间（秒）为 0.58（0.13），结肠镜检查后为 0.61（0.13）；P =.50。
样本量小，单中心研究。
尽管在接受异丙酚镇静后 1 小时内数字连接测试和驾驶模拟（精神运动恢复）测试的结果一致，但在普遍推荐这些结果之前，还需要对更多患者和不同患者群体进行研究。
