Matsumoto Takunori, Hosoya Tsuyoshi, Tomoda Hiroshi, Shiro Motoo, Shigemori Hideyuki
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305–8572, Japan.
Chem Pharm Bull (Tokyo). 2011;59(12):1559-61. doi: 10.1248/cpb.59.1559.
Two new antimicrobial chlorinated cyclopentenones, palmaenones A (1) and B (2) were isolated from the culture broth of discomycete Lachnum palmae (NBRC-106495), and the structures of 1 and 2 were elucidated by spectroscopic data and the stereochemistry of 1 was directly determined by a single-crystal X-ray diffraction analysis. Palmaenones A (1) and B (2) are cyclopentenones containing three chlorines. Compound 1 exhibited potent antimicrobial activity against Micrococcus luteus, Mycobacterium smegmatis, Escherichia coli, Xanthomonas campestris, and Mucor racemosus, while the activities of compound 2 were weaker than 1.
从盘菌Lachnum palmae（NBRC - 106495）的培养液中分离出两种新型抗菌氯化环戊烯酮，即棕榈烯酮A（1）和B（2），通过光谱数据阐明了1和2的结构，并通过单晶X射线衍射分析直接确定了1的立体化学结构。棕榈烯酮A（1）和B（2）是含有三个氯原子的环戊烯酮。化合物1对藤黄微球菌、耻垢分枝杆菌、大肠杆菌、野油菜黄单胞菌和总状毛霉表现出强效抗菌活性，而化合物2的活性比1弱。
