Diaporphasines E and F: New Polyketides from the Saprotrophic Fungus sp. IW157 Growing on the Reed Grass .

Chemical investigation for the mycelial extract of a saprotrophic fungus sp. IW157 growing on the common reed grass afforded the identification of two polyketide metabolites diaporphasines E () and F (). Chemical structures of isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR spectral analyses in addition to their high-resolution mass spectrometry. The isolated compounds were assessed for their cytotoxicity and antimicrobial and biofilm inhibitory activities. While compound revealed potent cytotoxicity against the tested cell lines L929 and KB3.1 with IC values of 0.9 and 3.7 μM, respectively, compound exhibited moderate effects on the formation of biofilms at 31.25 μg/mL.