Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília-UCB, Brasília-DF, Brazil.
BMC Cardiovasc Disord. 2011 Dec 2;11:71. doi: 10.1186/1471-2261-11-71.
The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2-) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype.
Participants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO2- measured before and after experimental sessions.
Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2- release was observed only for carriers of the I allele (p < 0.05).
Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.
血管紧张素转换酶（ACE）基因 I 等位基因的缺失与循环 ACE 水平升高、一氧化氮（NO）释放减少和高血压有关。本研究的目的是分析根据 ACE 基因型分为不同组的老年女性在不同运动强度下运动后唾液亚硝酸盐（NO2-）和血压（BP）的反应。
参与者（n = 30；II/ID = 20，DD = 10）进行了三项实验：递增测试 - IT（15 瓦工作量增加/3 分钟）直至力竭；20 分钟运动 90%无氧阈值（90% AT）；以及 20 分钟无运动的对照期。志愿者在实验前后测量 BP 和 NO2-。
尽管两种强度与对照组相比，在运动后恢复期间都对防止 BP 升高有保护作用，但只有携带 I 等位基因的个体（p < 0.05）才观察到运动后低血压和 NO2-释放增加。
ACE 基因的基因型可能在运动后 NO 释放和 BP 反应中发挥作用。
