Department of Cancer Epidemiology, Cancer Institute Chinese Academy of Medical Sciences, Beijing, China.
Nutr Cancer. 2012;64(1):48-56. doi: 10.1080/01635581.2012.630166. Epub 2011 Dec 2.
The objective was to provide an evidence-based, systematic assessment of the burden of cancer due to overweight/obesity and physical inactivity in China. This study evaluated the proportion of cancers of colon, rectum, pancreas, breast (postmenopausal), endometrium, and kidney attributable to overweight [30 kg/m(2) > body mass index (BMI) ≥ 25 kg/m(2))/obesity (BMI ≥ 30 kg/m(2)) and physical inactivity in China in 2005. Data of prevalence of overweight/obesity and lack of physical activity were derived from cross-sectional surveys among representative samples of Chinese population, and data of relative risks on cancers were derived from meta-analyses or large-scale studies from China and East Asian populations. The attributable fractions were calculated by combining both data of prevalence and relative risks. In China in 2005, 0.32% of cancer deaths and 0.65% of cancer cases were attributable to overweight and obesity combined. Lack of physical activity was responsible for 0.27% of cancer deaths and 0.39% of cancer cases. Future projections indicate that the contribution of overweight and obesity to the overall cancer burden will increase in the next decades. The largest increased attributable fractions will be for endometrial cancer. The increase in attributable fractions would be greater in men and in rural populations. Although the current burden of cancer associated with overweight/obesity and physical inactivity is still relatively small in China, it is expected to increase in the future.
目的在于提供一个基于证据的、系统的评估超重/肥胖和缺乏身体活动对中国癌症负担的影响。本研究评估了 2005 年中国因超重[30kg/m(2)>体重指数（BMI）≥25kg/m(2)]/肥胖（BMI≥30kg/m(2)）和缺乏身体活动而导致的结肠癌、直肠癌、胰腺癌、乳腺癌（绝经后）、子宫内膜癌和肾癌的比例。超重/肥胖和缺乏身体活动的流行数据来自中国代表性人群的横断面调查，癌症的相对风险数据来自中国和东亚人群的荟萃分析或大型研究。归因分数是通过结合流行数据和相对风险数据计算得出的。2005 年，中国有 0.32%的癌症死亡和 0.65%的癌症病例归因于超重和肥胖。缺乏身体活动导致 0.27%的癌症死亡和 0.39%的癌症病例。未来的预测表明，超重和肥胖对整体癌症负担的贡献将在未来几十年内增加。子宫内膜癌的归因分数增加幅度最大。男性和农村人口的归因分数增加幅度将更大。尽管目前与超重/肥胖和缺乏身体活动相关的癌症负担在中国仍然相对较小，但预计未来会增加。
