鲍曼不动杆菌中与替加环素相关的 blaNDM 样基因的获得。
Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii.
机构信息
Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2012 Feb;56(2):1087-9. doi: 10.1128/AAC.05620-11. Epub 2011 Dec 5.
Abstract
A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.
摘要
一株从一名曾在塞尔维亚住院、后转移至瑞士的患者身上分离出的耐多药鲍曼不动杆菌分离株产生了 NDM-1 碳青霉烯酶。bla(NDM-1)基因位于 Tn125 转座子的染色体定位上，该转座子由两个相同插入序列 ISAba125 框定。该转座子还与德国一株鲍曼不动杆菌分离株 bla(NDM-2)基因的获得和表达有关。Tn125 似乎是该物种 bla(NDM)基因传播的主要载体。
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