人多能干细胞使呼吸与能量产生脱耦。
Human pluripotent stem cells decouple respiration from energy production.
机构信息
Stem Cell Program, Children's Hospital Boston, Boston, MA, USA.
出版信息
EMBO J. 2011 Dec 14;30(24):4851-2. doi: 10.1038/emboj.2011.436.
Abstract
EMBO J 30 24, 4860–4873 (2011); published online November 15 2011 Human pluripotent stem cells (hPSCs) rely heavily on glycolysis for energy metabolism, and because their mitochondria appear poorly developed, hPSCs have been assumed to be incapable of using oxidative phosphorylation (OxPhos). In this issue, Zhang et al (2011) demonstrate that hPSCs actually possess functional OxPhos machinery, but that the mitochondrial protein UCP2 decouples OxPhos from glycolysis. The study further suggests that regulation of glucose metabolism by UCP2 facilitates hPSC pluripotency and controls hPSC differentiation.
摘要
EMBO J 30 24, 4860–4873 (2011); published online November 15 2011 人类多能干细胞（hPSCs）在能量代谢上严重依赖糖酵解，而且由于它们的线粒体似乎发育不良，hPSCs 一直被认为不能进行氧化磷酸化（OxPhos）。在本期杂志中，Zhang 等人（2011）证明 hPSCs 实际上拥有功能性的 OxPhos 机制，但线粒体蛋白 UCP2 将 OxPhos 与糖酵解解偶联。该研究进一步表明，UCP2 对葡萄糖代谢的调节促进了 hPSC 的多能性，并控制着 hPSC 的分化。
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