Sitara D, Hoffbrand B I
Department of Medicine, Whittington Hospital, London, UK.
Postgrad Med J. 1990 Aug;66(778):669-71. doi: 10.1136/pgmj.66.778.669.
Two patients with long-standing chronic bronchial suppuration developed antineutrophil cytoplasmic antibody (ANCA) positive Wegener's granulomatosis and microscopic polyarteritis respectively. There is published evidence of an association between previous suppurative respiratory disease and Wegener's granulomatosis. We believe that our cases provide further evidence that chronic lung infection may play an aetiological role in the development of ANCA-positive systemic necrotizing vasculitis in some individuals.
两名患有长期慢性支气管化脓症的患者分别发展为抗中性粒细胞胞浆抗体（ANCA）阳性的韦格纳肉芽肿和显微镜下多动脉炎。已有文献证明既往化脓性呼吸道疾病与韦格纳肉芽肿之间存在关联。我们认为，我们的病例进一步证明，在某些个体中，慢性肺部感染可能在ANCA阳性系统性坏死性血管炎的发生中起病因学作用。
