新生儿狼疮的心脏表现：自身抗体相关性先天性心脏传导阻滞及其对成年人群影响的综述。
Cardiac manifestations of neonatal lupus: a review of autoantibody-associated congenital heart block and its impact in an adult population.
机构信息
Department of Pediatrics, Children's Hospital of Montefiore, Bronx, NY, USA.
出版信息
Cardiol Rev. 2012 Mar-Apr;20(2):72-6. doi: 10.1097/CRD.0b013e31823c808b.
Abstract
Within the last decade the prevalence of adult patients living with congenital heart disease equals that seen in children. This expanding population poses a challenge to clinical cardiologists who will be caring for patients with the clinical manifestations of this condition. Neonatal lupus is a model of passively acquired autoimmunity and is responsible for the majority of clinical cases of congenital heart block (CHB). This review will focus on the presentation, pathophysiology, and the long-term follow-up of CHB associated with neonatal lupus, and discuss important diagnostic tests, familial implications, and pacemaker issues associated with the care of an adult with CHB.
摘要
在过去的十年中，患有先天性心脏病的成年患者的患病率与儿童患者相当。这一不断扩大的人群给临床心脏病专家带来了挑战，他们将负责治疗患有这种疾病临床表现的患者。新生儿狼疮是被动获得自身免疫的一个模型，也是导致大多数先天性心脏传导阻滞（CHB）临床病例的原因。这篇综述将重点讨论与新生儿狼疮相关的 CHB 的临床表现、病理生理学和长期随访，并讨论与 CHB 成年患者护理相关的重要诊断测试、家族影响和起搏器问题。
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