Department of Bioscience and Oral Diagnosis, São Jose dos Campos School of Dentistry, Universidade Estadual Paulista (UNESP), São José dos Campos, SP, Brazil.
J Mater Sci Mater Med. 2012 Feb;23(2):357-64. doi: 10.1007/s10856-011-4515-0. Epub 2011 Dec 20.
A porous implant material with adequate pore structure and the appropriate mechanical properties for bone ingrowth has long been sought. This article presents details of the development, characterization and in vivo evaluations of powder metallurgy-processed titanium samples exhibiting a dense core with an integrated porous surface for biomedical applications. A space-holder method was applied to investigate the effects of different percentages and particle sizes of the urea on bone neoformation in 30 rabbits. The samples were previously characterized using scanning electron microscopy and mechanical testing. After 8 and 12 weeks of implantation, bone ingrowth was histologically and histometrically analyzed and push-out testing was performed. This study demonstrated that the association of a dense core integrated with the greatest number of interconnected pores of the smallest size is a promising biomaterial for bone tissue engineering. This sample exhibits appropriate mechanical properties combined with increased bone ingrowth, providing enhanced resistance to displacement.
一种具有足够的孔隙结构和适合骨长入的适当机械性能的多孔植入材料一直以来都备受关注。本文详细介绍了粉末冶金工艺制备的钛样品的开发、表征和体内评价，这些样品具有致密的芯部和集成的多孔表面，可用于生物医学应用。本文采用造孔剂法研究了不同百分比和粒径的尿素对 30 只兔子新骨形成的影响。样品之前使用扫描电子显微镜和机械测试进行了表征。在植入 8 周和 12 周后，进行了组织学和组织计量学分析以及推出试验。本研究表明，致密芯部与数量最多的最小尺寸相互连通的孔隙相结合是一种很有前途的骨组织工程生物材料。该样品具有适当的机械性能和增加的骨长入，提供了增强的抗移位能力。
