Department of Biomedical Engineering, University of California, Davis, CA, USA.
Lab Anim (NY). 2011 Dec 19;41(1):20-5. doi: 10.1038/laban0112-20.
Osteoarthritis affects one in eight American adults over the age of 25 y and is a leading cause of chronic disability in the US. Translational research to investigate treatments for this naturally occurring joint disease requires an appropriate animal model. The authors conducted a retrospective study to assess the potential of naturally occurring osteoarthritis in the domestic rabbit as a model of the human disease. Analysis of radiographic images showed that the presence and severity of osteoarthritis were significantly influenced by both age and body weight. The most commonly affected joints were the knee and the hip. The findings reported here suggest that the rabbit is an excellent model of spontaneously arising osteoarthritis that may be useful in translational research pertaining to the human disease.
骨关节炎影响每 8 个 25 岁以上的美国成年人，是美国慢性残疾的主要原因。为了研究这种自然发生的关节疾病的治疗方法，需要一种适当的动物模型。作者进行了一项回顾性研究，评估了家兔的自然发生的骨关节炎作为人类疾病模型的潜力。放射影像分析表明，骨关节炎的存在和严重程度受到年龄和体重的显著影响。最常受影响的关节是膝盖和臀部。这里报告的研究结果表明，家兔是自发性骨关节炎的极佳模型，可能对与人类疾病相关的转化研究有用。
