Amira Smain, Dade Martin, Schinella Guillemo, Ríos José-Luis
Department of Biology, University Ferhat Abbas, Setif, Algeria.
Pak J Pharm Sci. 2012 Jan;25(1):65-72.
The aim of this research was to study the potential anti-inflammatory activity of myrtle (Myrtus communis), sarsaparilla (Smilax aspera), Arabian or French lavender (Lavandula stoechas), and calamint (Calamintha nepeta) along with their apoptotic effects on the pro-inflammatory cells, and the correlation of these effects with the plants' potential anti-oxidant activity. Myrtle extract exhibited the highest inhibitory activity in the paw oedema induced by carrageenan (60% at 3 h), whereas calamint, lavender, and sarsaparilla produced inhibitions of 49%, 38%, and 47%, respectively. None of them had an effect on the TPA-induced ear oedema. Moreover, all the extracts except sarsaparilla showed different degrees of anti-oxidant activity. Lavender and myrtle at 200 μg/mL decreased cell viability by 63% and 59%, respectively, after 3 h of incubation. Neutrophil elimination through apoptosis could be implicated in the resolution of acute inflammation in the case of lavender, whereas the reduction of reactive oxygen species produced by neutrophils, such as the superoxide anion and the hydroxyl radical, could be implicated in the overall reduction of inflammation. These results may support the traditional use of these plants.
本研究的目的是研究香桃木（Myrtus communis）、菝葜（Smilax aspera）、阿拉伯薰衣草或法国薰衣草（Lavandula stoechas）以及风轮菜（Calamintha nepeta）的潜在抗炎活性，及其对促炎细胞的凋亡作用，以及这些作用与植物潜在抗氧化活性的相关性。香桃木提取物对角叉菜胶诱导的爪部水肿表现出最高的抑制活性（3小时时为60%），而风轮菜、薰衣草和菝葜的抑制率分别为49%、38%和47%。它们对佛波酯诱导的耳部水肿均无作用。此外，除菝葜外，所有提取物均表现出不同程度的抗氧化活性。孵育3小时后，200μg/mL的薰衣草和香桃木分别使细胞活力降低63%和59%。对于薰衣草而言，通过凋亡消除中性粒细胞可能与急性炎症的消退有关，而中性粒细胞产生的活性氧如超氧阴离子和羟基自由基的减少可能与炎症的总体减轻有关。这些结果可能支持这些植物的传统用途。
