Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Magn Reson Med. 2012 Aug;68(2):349-52. doi: 10.1002/mrm.23231. Epub 2011 Dec 21.
In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-(13)C(2)] and sodium [1-(13)C] acetate. The method presented herein leads to highly enhanced in vivo detection of short-T(1) (13)C as well as attached protons. This indirect detection scheme allows for probing additional molecular sites in hyperpolarized substrates and their metabolites and can thus lead to improved spectral resolution such as in the case of (13)C-acetate metabolism.
在 9.4T 下，通过向大鼠脑内输注超极化的[1,2-(13)C2]和[1-(13)C]醋酸钠，设计并进行了体内局部和完全绝热的同核和异核极化转移实验。本文所提出的方法可高度提高体内对短 T1（13）C 以及与其相连的质子的检测能力。这种间接检测方案可用于探测超极化底物及其代谢物中的其他分子部位，从而提高谱分辨率，如在（13）C-醋酸盐代谢的情况下。
