金纳米棒在哨点淋巴结中摄取的三维高分辨率成像。
Three-dimensional high-resolution imaging of gold nanorods uptake in sentinel lymph nodes.
机构信息
Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, Washington 98195, United States.
出版信息
Nano Lett. 2011 Jul 13;11(7):2938-43. doi: 10.1021/nl2014394. Epub 2011 Jun 17.
Abstract
In this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time dependent. Finally, we determine the average concentration of GNRs within the whole SLN which is used to demonstrate uptake kinetics of the nanoparticles.
摘要
在本文中，我们展示了一种无创成像模式——光热光学相干断层扫描（PT-OCT）在原位成像小鼠前哨淋巴结（SLN）中纳米金棒（GNRs）摄取的应用。由于 GNRs 的光热对比特性，这种应用使我们能够获得更高质量的 SLN 结构图像。此外，还证明了 GNRs 在几个 SLN 结构内的积累方式不同，并且这种摄取是时间依赖性的。最后，我们确定了整个 SLN 中 GNRs 的平均浓度，用于演示纳米颗粒的摄取动力学。
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