Schmitz J P J, Vanlier J, van Riel N A W, Jeneson Jeroen A L
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Crit Rev Biomed Eng. 2011;39(5):363-77. doi: 10.1615/critrevbiomedeng.v39.i5.20.
Mitochondria are the power plant of the heart, burning fat and sugars to supply the muscle with the adenosine triphosphate (ATP) free energy that drives contraction and relaxation during each heart beat. This function was first captured in a mathematical model in 1967. Today, interest in such a model has been rekindled by ongoing in silico integrative physiology efforts such as the Cardiac Physiome project. Here, the status of the field of computational modeling of mitochondrial ATP synthetic function is reviewed.
线粒体是心脏的动力工厂，通过燃烧脂肪和糖分，为心肌提供三磷酸腺苷（ATP）自由能，驱动每次心跳时的收缩和舒张。这一功能最早在1967年的一个数学模型中得以体现。如今，诸如心脏生理组项目这样正在进行的计算机整合生理学研究，重新点燃了人们对该模型的兴趣。在此，我们对线粒体ATP合成功能计算建模领域的现状进行综述。
